G
Germaine Escames
Researcher at University of Granada
Publications - 179
Citations - 11449
Germaine Escames is an academic researcher from University of Granada. The author has contributed to research in topics: Melatonin & Mitochondrion. The author has an hindex of 58, co-authored 162 publications receiving 10059 citations. Previous affiliations of Germaine Escames include University of Texas Health Science Center at San Antonio & University of Texas at San Antonio.
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Journal ArticleDOI
Extrapineal melatonin: sources, regulation, and potential functions.
Darío Acuña-Castroviejo,Germaine Escames,Carmen Venegas,María E. Díaz-Casado,Elena Lima-Cabello,Luis C. López,Sergio Rosales-Corral,Dun Xian Tan,Russel J. Reiter +8 more
TL;DR: The presence of melatonin in extrapineal organs, tissues, and fluids of mammals including humans is emphasized and information related to its peripheral production and regulation of this ubiquitously acting indoleamine is compiled.
Journal ArticleDOI
Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations
Carmen Venegas,Jose A. García,Germaine Escames,Francisco Ortiz,Ana López,Carolina Doerrier,Laura García-Corzo,Luis C. López,Russel J. Reiter,Darío Acuña-Castroviejo +9 more
TL;DR: In this article, the subcellular levels of melatonin in cerebral cortex and liver of rats under several conditions were studied, and it was shown that melatonin levels in the cell membrane, cytosol, nucleus, and mitochondrion vary over a 24-hr cycle, although these variations do not exhibit circadian rhythms.
Journal ArticleDOI
Melatonin, mitochondria, and cellular bioenergetics.
Darío Acuña-Castroviejo,Miguel Martín,Manuel Macías,Germaine Escames,Josefa León,Huda Khaldy,Russel J. Reiter +6 more
TL;DR: Melatonin has been reported to exert neuroprotective effects in several experimental and clinical situations involving neurotoxicity and/or excitotoxicity, and in a series of pathologies in which high production of free radicals is the primary cause of the disease, melatonin is also protective.
Journal ArticleDOI
Melatonin but not vitamins C and E maintains glutathione homeostasis in t-butyl hydroperoxide-induced mitochondrial oxidative stress.
TL;DR: Melatonin, but not vitamins C and E, prevents the toxic effects of hydroperoxides on mitochondria by regenerating their GSH content.
Journal ArticleDOI
Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation
Joaquin J. Garcia,Russel J. Reiter,Juan M. Guerrero,Germaine Escames,Byung Pal Yu,Chang S Oh,A. Muñoz-Hoyos +6 more
TL;DR: Melatonin's protective effect may relate to its known ability to scavenge free radicals and function as an antioxidant.