G
Gert De Wilde
Researcher at Ghent University
Publications - 8
Citations - 1473
Gert De Wilde is an academic researcher from Ghent University. The author has contributed to research in topics: Death domain & Regulation of gene expression. The author has an hindex of 6, co-authored 8 publications receiving 1441 citations.
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Journal ArticleDOI
Transcriptional activation of the NF‐κB p65 subunit by mitogen‐ and stress‐activated protein kinase‐1 (MSK1)
TL;DR: It is shown that the mitogen‐activated protein kinase inhibitors SB203580 and PD98059 or U0126, as well as a potentMitogen‐ and stress‐ activatedprotein kinase‐1 (MSK1) inhibitor H89, counteract tumor necrosis factor (TNF)‐mediated stimulation of p65 transactivation capacity.
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Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6.
Wim Vanden Berghe,Linda Vermeulen,Gert De Wilde,Karolien De Bosscher,Elke Boone,Guy Haegeman +5 more
TL;DR: It is postulated that other components of the enhanceosome complex are sensitive to MAPK cascades and found that MAPK activity is unequivocally linked to the histone acetylation capacity of the enhancesosome to stimulate gene expression in response to TNF.
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Regulation of the transcriptional activity of the nuclear factor-κB p65 subunit
TL;DR: How other posttranslational modifications, such as acetylation and methylation of transcription factors or of the chromatin environment, may also affect NF-κB transcriptional activity is described.
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Activation of p42/p44 mitogen-activated protein kinases (MAPK) and p38 MAPK by tumor necrosis factor (TNF) is mediated through the death domain of the 55-kDa TNF receptor
TL;DR: It is demonstrated that TNF‐R55 is sufficient to activate p42/p44 MAPK and p38 MAPK, and it is shown that the intracellular death domain of T NF‐R 55 is the crucial domain involved.
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Structure/Function analysis of p55 tumor necrosis factor receptor and fas-associated death domain. Effect on necrosis in L929sA cells.
Elke Boone,Tom Vanden Berghe,Geert van Loo,Gert De Wilde,Nico De Wael,Dominique Vercammen,Walter Fiers,Guy Haegeman,Peter Vandenabeele +8 more
TL;DR: It is demonstrated that the death domain of FADD can elicit an active necrotic cell death pathway in TNF-R55-mediated necrosis.