G
Gilles Spenlehauer
Researcher at Rhône-Poulenc
Publications - 33
Citations - 2327
Gilles Spenlehauer is an academic researcher from Rhône-Poulenc. The author has contributed to research in topics: Polymer & Lactic acid. The author has an hindex of 18, co-authored 33 publications receiving 2277 citations. Previous affiliations of Gilles Spenlehauer include University of Paris-Sud & Aventis Pharma.
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Journal ArticleDOI
Stealth Me.PEG‐PLA nanoparticles avoid uptake by the mononuclear phagocytes system
Didier Bazile,Christian Prud'homme,Marie‐Theérèse Bassoullet,Michel Marlard,Gilles Spenlehauer,Michel Veillard +5 more
TL;DR: Nanoparticles prepared from methoxy poly(ethylene glycol)poly(d,l-lactic acid) block copolymers or blends of Me.PEG-PLA and PLA were shown to be more slowly captured by cultured THP-1 monocytes than F68-coated PLA nanoparticles, in a PEG chain-length-dependent manner.
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In vitro and in vivo degradation of poly(D,L lactide/glycolide) type microspheres made by solvent evaporation method.
TL;DR: Scanning electron microscopy of microsphere degradation in vitro correlated with the former observations, and the degradation rate of the polymers increased with the glycolic unit content in the lactic chains.
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Non-stealth (poly(lactic acid/albumin)) and stealth (poly(lactic acid-polyethylene glycol)) nanoparticles as injectable drug carriers
Thierry Verrecchia,Gilles Spenlehauer,Didier Bazile,A. Murry-Brelier,Y. Archimbaud,Michel Veillard +5 more
TL;DR: PLAPEG nanoparticles can be considered as a sustained release parenteral (intravenous) dosage form and significantly increases the plasma half-life of the colloidal carrier (‘stealth nanoparticles’).
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Effect of PEO surface density on long-circulating PLA-PEO nanoparticles which are very low complement activators.
Michaëlla Vittaz,Didier Bazile,Gilles Spenlehauer,Thierry Verrecchia,Michel Veillard,Francis Puisieux,Denis Labarre +6 more
TL;DR: Experimental data support the concept of steric repulsion towards proteins, by surfaces covered with terminally attached PEO chains and emphasize the prime importance of PEO surface density in such an effect.
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Body distribution of fully biodegradable [14C]-poly(lactic acid) nanoparticles coated with albumin after parenteral administration to rats
Didier Bazile,C. Ropert,P. Huve,Thierry Verrecchia,M. Mariard,A. Frydman,Michel Veillard,Gilles Spenlehauer +7 more
TL;DR: As deduced from whole-body autoradiography and quantitative distribution experiments, the 14C-labelled polymer is rapidly captured by liver, bone marrow, lymph nodes, spleen and peritoneal macrophages, by incorporation of 14C into endogenous compounds.