G
Giovanna Buttice
Researcher at Dartmouth College
Publications - 2
Citations - 584
Giovanna Buttice is an academic researcher from Dartmouth College. The author has contributed to research in topics: Gene expression & Transcription factor. The author has an hindex of 2, co-authored 2 publications receiving 575 citations.
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Journal Article
A Single Nucleotide Polymorphism in the Matrix Metalloproteinase-1 Promoter Creates an Ets Binding Site and Augments Transcription
Joni L. Rutter,Teresa I. Mitchell,Giovanna Buttice,Jennifer Meyers,James F. Gusella,Laurie J. Ozelius,Constance E. Brinckerhoff +6 more
TL;DR: This MMP-1 polymorphism contributes to increased transcription, and cells expressing the 2 G polymorphism may provide a mechanism for more aggressive matrix degradation, thereby facilitating cancer progression.
Journal ArticleDOI
High levels of MMP-1 expression in the absence of the 2G single nucleotide polymorphism is mediated by p38 and ERK1/2 mitogen-activated protein kinases in VMM5 melanoma cells.
TL;DR: The data suggest that tumor cells may use alternative signal/transduction pathways and cis‐acting sequences to achieve high levels of MMP‐1 expression, which contribute to the ability of tumor cells to invade, regardless of their genotype.