Giuliano Neri

TL;DR: IL-1β was found to dose-dependently raise corticosterone (B) blood concentration in hypophysectomized rats, without inducing any significant increase in the level of circulating ACTH, and the secretory effect of IL-1 β was completely blocked by both α-helical-CRF and corticotropin-inhibiting peptide.

TL;DR: Ghrelin and GHS‐R are both expressed in the rat adrenal cortex, ghrelin binding sites being very abundant in the ZG, and gh Relin does not affect the secretory activity of rat adrenocortical cells, but significantly enhances the proliferation rate of cultured ZG cells, without affecting apoptotic deletion rate.

TL;DR: Findings indicate that in the rat, the adrenocortical secretagogue action of ET-1 is mediated by the ET(B) receptor subtype and that theET(A) receptor is not directly involved in such an effect.

TL;DR: Findings suggest that ADM, acting via the CGRP1 receptor subtype, exerts a direct inhibitory effect on angiotensin II-stimulated aldosterone secretion, which, when the integrity of adrenal tissue is preserved, is overcome and reversed by an indirect stimulatory action, conceivably involving the release of catecholamines by adrenal chromaffin cells.

TL;DR: It was concluded that TRH is an inhibitor of glucocorticoid secretion in rats, which electively impairs the late steps of B synthesis without affecting the earlier steps, including the rate-limiting one of this process.