G
Giuseppe Mameli
Researcher at University of Sassari
Publications - 54
Citations - 1990
Giuseppe Mameli is an academic researcher from University of Sassari. The author has contributed to research in topics: Multiple sclerosis & Antibody. The author has an hindex of 24, co-authored 52 publications receiving 1716 citations. Previous affiliations of Giuseppe Mameli include University Health System.
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Journal ArticleDOI
Brains and peripheral blood mononuclear cells of multiple sclerosis (MS) patients hyperexpress MS-associated retrovirus/HERV-W endogenous retrovirus, but not Human herpesvirus 6.
Giuseppe Mameli,Vito Astone,Giannina Arru,Silvia Marconi,Laura Lovato,Caterina Serra,Stefano Sotgiu,Bruno Bonetti,Antonina Dolei +8 more
TL;DR: It is indicated that MSRV/HERV-W is expressed actively in human brain and activated strongly in MS patients, whilst there are no significant differences between these MS patients and controls for HHV-6 presence/replication at the brain or PBMC level.
Journal ArticleDOI
Expression and activation by Epstein Barr virus of human endogenous retroviruses-W in blood cells and astrocytes: inference for multiple sclerosis.
Giuseppe Mameli,L Poddighe,Alessandra Mei,Elena Uleri,Stefano Sotgiu,Caterina Serra,Roberto Manetti,Antonina Dolei +7 more
TL;DR: In MS pathogenesis, a possible model could include EBV as initial trigger of future MS, years later, and HERV-W/MSRV/syncytin-1 as actual contributor to MS pathogenicity, in striking parallelism with disease behaviour.
Journal ArticleDOI
Multiple sclerosis-associated retrovirus (MSRV) in Sardinian MS patients.
Antonina Dolei,Caterina Serra,Giuseppe Mameli,Maura Pugliatti,GianPietro Sechi,M.C. Cirotto,Giulio Rosati,Stefano Sotgiu +7 more
TL;DR: Blood and CSF of Sardinian patients with MS and neurologic control subjects were tested for MS-associated retrovirus (MSRV), and MSRV was detected in all MS patients, in most patients with inflammatory neurologic diseases, and rarely in healthy blood donors.
Journal ArticleDOI
Multiple sclerosis-associated retrovirus and MS prognosis: an observational study.
Stefano Sotgiu,Caterina Serra,Giuseppe Mameli,Maura Pugliatti,Giulio Rosati,Giannina Arru,Antonina Dolei +6 more
TL;DR: A MS-associated retrovirus in the CSF may have gliotoxic properties and could be associated with a more disabling MS, and this hypothesis was tested in untreated patients with MS.
Journal ArticleDOI
Novel reliable real-time PCR for differential detection of MSRVenv and syncytin-1 in RNA and DNA from patients with multiple sclerosis
Giuseppe Mameli,L Poddighe,Vito Astone,Giuseppe Delogu,Giannina Arru,Stefano Sotgiu,Caterina Serra,Antonina Dolei +7 more
TL;DR: DNA copy numbers were more abundant in MS patients than in healthy humans, while syncytin-1 were unchanged, reinforcing the link between MSRV and MS.