Showing papers by "Giuseppe Paglietti published in 2005"
TL;DR: The antimycobacterial activity of new quinoxaline derivatives against clinical isolates of Mycobacterium tuberculosis and other mycobacteria is described and intracellular action of these drugs in mouse macrophages is observed.
28 citations
TL;DR: In this paper, a tricyclic triazolobenzotriazole was obtained for the first time, which was called 5,5'( Z )-diazene-1,2-diylbis(2-methyl-2 H -1, 2,2,3-benzotrizole).
Abstract: Nitration of 5-chlorobenzotriazole ( 1 ) and its N1 -methyl derivatives ( 2 and 3 ) produced 5-chloro-4-nitrobenzotriazole ( 5 ), 5-chloro-1-methyl-4-nitrobenzotriazole ( 6 ) and 6-chloro-1-methyl-7-nitrobenzotriazole ( 7 ) respectively. Nitration of 5-chloro-2-methylbenzotriazole ( 4 ) gave either 5-chloro-2-methyl-4-nitrobenzotriazole ( 8 ) or 5-chloro-2-methyl-4,6-dinitrobenzotriazole ( 9 ). Introduction of the nitro group activated chlorine atom that underwent nucleophilic displacement by hydrazine to give rise to a new tricyclic system 1 H ,6 H -triazolo[4,5- e ]benzotriazole-3-oxide compounds ( 10 and 11 ) in the case of 5 and 6 . From 9 no linear or angular tricyclic triazolobenzotriazole was obtained but instead the 5,5’( Z )-diazene-1,2-diylbis(2-methyl-2 H -1,2,3-benzotriazole).
7 citations