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Giuseppe Pontrelli
Researcher at Boston Children's Hospital
Publications - 136
Citations - 2859
Giuseppe Pontrelli is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Lattice Boltzmann methods & Drug delivery. The author has an hindex of 27, co-authored 121 publications receiving 2255 citations. Previous affiliations of Giuseppe Pontrelli include University of Bari & Istituto Superiore di Sanità.
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Journal ArticleDOI
Biomimetic Nanotherapies: Red Blood Cell Based Core-Shell Structured Nanocomplexes for Atherosclerosis Management.
Yi Wang,Kang Zhang,Xian Qin,Tianhan Li,Juhui Qiu,Tieying Yin,Junli Huang,Sean McGinty,Giuseppe Pontrelli,Jun Ren,Qiwei Wang,Wei Wu,Guixue Wang +12 more
TL;DR: This study demonstrates the therapeutic advantages of biomimetic nanotherapy for Atherosclerosis treatment, which holds considerable promise as a new generation of drug delivery system for safe and efficient management of atherosclerosis.
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EPI-743 reverses the progression of the pediatric mitochondrial disease—Genetically defined Leigh Syndrome
Diego Martinelli,Michela Catteruccia,Fiorella Piemonte,Anna Pastore,Giulia Tozzi,Carlo Dionisi-Vici,Giuseppe Pontrelli,Tiziana Corsetti,Susanna Livadiotti,Viktoria Kheifets,Andrew W. Hinman,William D. Shrader,Martin Thoolen,Matthew B. Klein,Enrico Bertini,Guy M. Miller +15 more
TL;DR: In comparison to the natural history of Leigh syndrome, EPI-743 improves clinical outcomes in children with genetically confirmed Leigh syndrome.
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Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications.
Yi Wang,Kang Zhang,Tianhan Li,Ali Maruf,Xian Qin,Li Luo,Yuan Zhong,Juhui Qiu,Sean McGinty,Giuseppe Pontrelli,Xiaoling Liao,Wei Wu,Guixue Wang +12 more
TL;DR: It is demonstrated that MM/RAPNPs could efficiently and safely inhibit the progression of AS and may be potential drug delivery systems for safe and effective anti-AS applications.
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Mass diffusion through two-layer porous media: an application to the drug-eluting stent
TL;DR: In this paper, a mathematical model for the diffusion-transport of a substance between two porous homogeneous media of different properties and dimensions is presented and a strong analogy with the one-dimensional transient heat conduction process across two-layered slabs is shown and a similar methodology of solution is proposed.
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A multi-layer porous wall model for coronary drug-eluting stents
TL;DR: An analytical solution for solving the transient drug diffusion in adjoining porous wall layers faced with a drug-eluting stent is presented in this article, where the endothelium, intima, internal elastic lamina and media are all treated as homogeneous porous media and the drug transfer through them is modelled by a set of coupled partial differential equations.