Showing papers by "Glenn M. Sammis published in 2003"
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TL;DR: Mechanistic data obtained thus far point to a cooperative bimetallic mechanism for nucleophile and electrophile activation.
Abstract: (Salen)Al−Cl complex 1a catalyzes the asymmetric conjugate addition of hydrogen cyanide to α,β-unsaturated imides in high yields and enantioselectivities. The cyanide adducts can readily be converted into a variety of useful chiral building blocks, including α-substituted-β-amino acids and β-substituted-γ-aminobutyric acids. Mechanistic data obtained thus far point to a cooperative bimetallic mechanism for nucleophile and electrophile activation.
231 citations
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TL;DR: In this paper, a cooperative bimetallic mechanism for nucleophile and electrophile activation has been proposed, based on the asymmetric conjugate addition of hydrogen cyanide to α,β-unsaturated imides in high yields and enantioselectivities.
Abstract: (Salen)Al−Cl complex 1a catalyzes the asymmetric conjugate addition of hydrogen cyanide to α,β-unsaturated imides in high yields and enantioselectivities. The cyanide adducts can readily be converted into a variety of useful chiral building blocks, including α-substituted-β-amino acids and β-substituted-γ-aminobutyric acids. Mechanistic data obtained thus far point to a cooperative bimetallic mechanism for nucleophile and electrophile activation.
4 citations