Goar Frishman

TL;DR: A ‘Phylogenetic Conservation’ analysis tool was implemented that analyses the potential occurrence of orthologous protein complex subunits in mammals and other selected groups of organisms and allows one to predict the occurrence of protein complexes in different phylogenetic groups.

TL;DR: The MIPS mammalian protein-protein interaction database (MPPI) is a new resource of high-quality experimental protein interaction data in mammals that is based on published experimental evidence that has been processed by human expert curators.

TL;DR: Using the PhenomiR dataset, it is demonstrated that, depending on disease type, independent information from cell culture studies contrasts with conclusions drawn from patient studies.

TL;DR: The second version of Negatome, a database of proteins and protein domains that are unlikely to engage in physical interactions, is presented and it is shown that nearly a half of the text mining results with the highest confidence values correspond to NIP pairs.

TL;DR: The Negatome is much less biased toward functionally dissimilar proteins than the negative data derived by randomly selecting proteins from different cellular locations and can be used to evaluate protein and domain interactions from new experiments and improve the training of interaction prediction algorithms.