G
Gonçalo J. L. Bernardes
Researcher at University of Cambridge
Publications - 212
Citations - 11286
Gonçalo J. L. Bernardes is an academic researcher from University of Cambridge. The author has contributed to research in topics: Chemistry & Bioconjugation. The author has an hindex of 47, co-authored 191 publications receiving 8432 citations. Previous affiliations of Gonçalo J. L. Bernardes include Instituto de Medicina Molecular & École Polytechnique Fédérale de Lausanne.
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Journal ArticleDOI
Advances in Chemical Protein Modification
TL;DR: This work is funded by the European Commission (Marie Curie CIG) and Ministerio de Ciencia e Innovacion, Spain (Juan de la Cierva Fellowship).
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Inverse electron demand Diels–Alder reactions in chemical biology
TL;DR: The exceptional fast kinetics of this catalyst-free reaction, even using low concentrations of coupling partners, make it amenable for in vivo radiolabelling using pretargeting methodologies, which are discussed.
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Chemical modification of proteins at cysteine: opportunities in chemistry and biology.
TL;DR: This Focus Review highlights the enduring utility of cysteine in protein modification with special focus on recent innovations in chemistry and biology associated with such modifications.
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Developing drug molecules for therapy with carbon monoxide
TL;DR: This tutorial review summarises the biological and chemical behaviour of CO, the current status ofCO-RM development, and derives principles for the creation of the next generation of CO-RMs for clinical applications in humans.
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Site-selective protein-modification chemistry for basic biology and drug development
Nikolaus Krall,Filipa P. da Cruz,Omar Boutureira,Gonçalo J. L. Bernardes,Gonçalo J. L. Bernardes +4 more
TL;DR: The most exciting current and future applications of chemical site-selective protein modification are highlighted and which hurdles still need to be overcome for more widespread use are considered.