Gopinath Kasetty

TL;DR: It is demonstrated that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely cheMERin-dependent.

TL;DR: Hydrophobic C-terminal end-tagging of the cationic sequence RRPRPRPRP generates highly selective AMPs with potent activity against multiresistant bacteria and efficiency in ex vivo wound infection models.

TL;DR: The generality of the high membrane selectivity for other peptides of this type is demonstrated, andReplacing cholesterol with ergosterol results in an increased sensitivity for peptide-induced lysis, in analogy to the antifungal properties of such peptides.

TL;DR: It is shown that the viability of fibrinogen-binding bacteria is affected in human plasma activated with thrombin, and it is found that the peptide fragment GHR28 released from the β-chain of fibinogen has antimicrobial activity against bacteria that bind fibr inogen to their surface, whereas non-binding strains are unaffected.

TL;DR: C-terminal TFPI peptide sequences are antimicrobial against the Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, Gram-positive Bacillus subtilis and Staphylococcus aureus, as well as the fungi Candida albicans and Candida parapsilosis.