Showing papers by "Govindasamy Mugesh published in 2017"
TL;DR: The redox modulatory effect of Mn3 O4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)-like cellular model, indicating that manganese-based nanomaterials having multi-enzyme activity can robustly rescue the Cells from oxidative damage and thereby possess therapeutic potential to prevent ROS-mediated neurological disorders.
Abstract: Nanomaterials with enzyme-like activities (nanozymes) attracts significant interest due to their therapeutic potential for the treatment of various diseases. Herein, we report that a Mn3 O4 nanozyme functionally mimics three major antioxidant enzymes, that is, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the multienzyme activity is size as well as morphology-dependent. The redox modulatory effect of Mn3 O4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)-like cellular model, indicating that manganese-based nanomaterials having multi-enzyme activity can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS-mediated neurological disorders.
389 citations
TL;DR: This review discusses on the development of small-molecule deiodinase mimetics and their mechanism of deiodination, as these compounds have the potential to regulate the thyroid hormone levels.
33 citations
01 Jan 2017
TL;DR: This chapter covers detailed information on the structure and functionalities present on the graphite oxide/graphene oxide and enzyme-mimetic properties of GO and GO-related materials and their applications.
Abstract: The structure of graphite oxide and functional groups present on it renders the remarkable properties and defines its novel applications. This chapter covers detailed information on the structure and functionalities present on the graphite oxide/graphene oxide. Apart from this, enzyme-mimetic properties of GO and GO-related materials and their applications are thoroughly discussed. The contents provided in this chapter may be useful for scientific community working in the field of material science, especially those engaged in graphene-related research. It may also benefit the people interested in the broad research areas of catalysis, bioinorganic chemistry, biomedical sciences, etc.