N
Namrata Singh
Researcher at Indian Institute of Science
Publications - 8
Citations - 738
Namrata Singh is an academic researcher from Indian Institute of Science. The author has contributed to research in topics: Superoxide dismutase & Nanoclusters. The author has an hindex of 6, co-authored 8 publications receiving 391 citations.
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A Redox Modulatory Mn3O4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model
Namrata Singh,Mohammed Azharuddin Savanur,Shubhi Srivastava,Patrick D'Silva,Govindasamy Mugesh +4 more
TL;DR: The redox modulatory effect of Mn3 O4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)-like cellular model, indicating that manganese-based nanomaterials having multi-enzyme activity can robustly rescue the Cells from oxidative damage and thereby possess therapeutic potential to prevent ROS-mediated neurological disorders.
Journal ArticleDOI
A manganese oxide nanozyme prevents the oxidative damage of biomolecules without affecting the endogenous antioxidant system.
Namrata Singh,Mohammed Azharuddin Savanur,Shubhi Srivastava,Patrick D'Silva,Govindasamy Mugesh +4 more
TL;DR: It is suggested that the multienzyme mimic Mn3O4 nanoparticles possess great potential in suppressing the oxidative stress-mediated pathophysiological conditions under which the antioxidant system is overwhelmed.
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A Cerium Vanadate Nanozyme with Specific Superoxide Dismutase Activity Regulates Mitochondrial Function and ATP Synthesis in Neuronal Cells
TL;DR: This work shows for the first time that a cerium vanadate (CeVO 4 ) nanozyme can substitute the function of superoxide dismutase 1 and 2 in the neuronal cells even when the natural enzyme is down-regulated by specific gene silencing.
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Manganese-Based Nanozymes: Multienzyme Redox Activity and Effect on the Nitric Oxide Produced by Endothelial Nitric Oxide Synthase.
TL;DR: It was found that Mn3 O4 nanoparticles mimic the functions of all three cellular antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and were found to be biocompatible, with very low cytotoxicity.
Journal ArticleDOI
CeVO 4 Nanozymes Catalyze the Reduction of Dioxygen to Water without Releasing Partially Reduced Oxygen Species
Namrata Singh,Govindasamy Mugesh +1 more
TL;DR: A remarkably active CeVO4 nanozyme is reported that functionally mimics cytochrome c oxidase (CcO), the terminal enzyme in the respiratory electron transport chain, by catalyzing a four-electron reduction of dioxygen to water.