Ultra-small optical probes comprising a single-mode optical fiber and a lens which has substantially the same diameter as the optical fiber. The optical fiber and lens are positioned in a probe housing which is in the form of an insertional medical device such as a guidewire. Connector elements are provided to facilitate the attachment of the probe to an optical system and the quick disconnection of the probe from the optical system. The probe is used to obtain optical measurements in situ in the body of an organism and can be used to guide interventional procedures by a surgeon.

Ultra-small optical probes, imaging optics, and methods for using same

Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.

Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands

An apparatus and method are provided. In particular, at least one first electro-magnetic radiation may be provided to a sample and at least one second electro-magnetic radiation can be provided to a non-reflective reference. A frequency of the first and/or second radiations varies over time. An interference is detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. Alternatively, the first electro-magnetic radiation and/or second electro-magnetic radiation have a spectrum which changes over time. The spectrum may contain multiple frequencies at a particular time. In addition, it is possible to detect the interference signal between the third radiation and the fourth radiation in a first polarization state. Further, it may be preferable to detect a further interference signal between the third and fourth radiations in a second polarization state which is different from the first polarization state. The first and/or second electro-magnetic radiations may have a spectrum whose mean frequency changes substantially continuously over time at a tuning speed that is greater than 100 Tera Hertz per millisecond.

Method and apparatus for performing optical imaging using frequency-domain interferometry

A system and method for imaging of a sample, e.g., biological sample, are provided. In particular, at least one source electro-magnetic radiation forwarded to the sample and a reference may be generated. A plurality of detectors may be used, at least one of the detectors capable of detecting a signal associated with a combination of at least one first electro-magnetic radiation received from the sample and at least one second electro-magnetic radiation received from the reference. At least one particular detector may have a particular electrical integration time, and can receive at least a portion of the signal for a time duration which has a first portion with a first power level greater than a predetermined threshold and a second portion immediately preceding or following the first portion. The second portion may have a second power level that is less than the predetermined threshold, and extends for a time period which may be, e.g., approximately more than 10% of the particular electrical integration time.

System and method for optical coherence imaging

Speckle, a factor reducing image quality in optical coherence tomography ('OCT'), can limit the ability to identify cellular structures that are important for the diagnosis of a variety of diseases. The present invention allows for an implementation of an angular compounding, angular compounding by path length encoding ('ACPE') for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and implements minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased signal-to-noise ratio ('SNR'). Accordingly, apparatus probe catheter, and method are provided for irradiating a sample. In particular, an interferometer (5) may forward forwarding an electromagnetic radiation (10). In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement (20) which facilitates a production of at least two radiations (30, 40) from the electromagnetic radiation so as to irradiate the sample. Such arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.

Speckle reduction in optical coherence tomography by path length encoded angular compounding

The invention is a rotary joint for singlemode optical fibers, having a fixed and a rotating part to permit the transmission of optical signals across a rotational interface (such as a winch or turret) with minimal insertion loss and, in particular, low reflections (good return loss). There is no need of conversion to electrical signals; the device is passive. It may be use an oil of refractive index matched to that of the glass fibers and to that of fiber tapers or lenses used to expand the beam emitted from one fiber and contract it for transmission into the other fiber. The device is bidirectional. By use foil, through precision techniques for building and mounting the optical and mechanical components, and by use of advanced bearings, both the insertion loss and unwanted reflections (return loss) can be minimized, thereby making it suitable for use with singlemode fiber. Insertion loss can be further reduced in conjunction with index-matching fluid by using optical elements (lenses, tapers, fibers) having angled or curved facets rather than perpendicular facets. Oil filling has the further advantage of pressure compensation allowing the device to operate at any ambient pressure. Lenses having curved surfaces can be accommodated by the use of fluid having a refractive index different from that of the lens material.

Fibre optic single mode rotary joint

The invention is a rotary joint for singlemode optical fibers, having a fixed and a rotating part to permit the transmission of optical signals across a rotational interface (such as a winch or turret) with minimal insertion loss and, in particular, low reflections (good return loss). There is no need of conversion to electrical signals; the device is passive. It may use an oil of refractive index matched to that of the glass fibers and to that of fiber tapers of lenses used to expand the beam emitted from one fiber and contract it for transmission into the other fiber. The device is bidirectional. By use of oil, through precision techniques for building and mounting the optical and mechanical components, and by use of advanced bearings, both the insertion loss and unwanted reflections (return loss) can be minimized, thereby making it suitable for use with singlemode fiber. Insertion loss can be further reduced in conjunction with index-matching fluid by using optical elements (lenses, tapers, fibers) having angled or curved facets rather than perpendicular facets. Oil filling has the further advantage of pressure compensation allowing the device to operate at any ambient pressure. Lenses having curved surfaces can be accomodated by the use of fluid having a refractive index different from that of the lens material.

Graham A. J. Smith

Papers

Fibre optic single mode rotary joint

Fibre optic rotary joint