G
Grant D. Nicol
Researcher at Indiana University
Publications - 44
Citations - 2666
Grant D. Nicol is an academic researcher from Indiana University. The author has contributed to research in topics: Nerve growth factor & Sensory neuron. The author has an hindex of 24, co-authored 44 publications receiving 2548 citations. Previous affiliations of Grant D. Nicol include Indiana University – Purdue University Indianapolis.
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Journal ArticleDOI
The cAMP Transduction Cascade Mediates the Prostaglandin E2 Enhancement of the Capsaicin-Elicited Current in Rat Sensory Neurons: Whole-Cell and Single-Channel Studies
John C. Lopshire,Grant D. Nicol +1 more
TL;DR: Modulation of the capsaicin-gated channel by the cAMP–protein kinase A signaling pathway enhanced the gating of these channels and consequently resulted in the sensitization of the whole-cell currents.
The cAMP transduction cascade mediates the prostaglandin E2 enhancement of the capsaicin-elicited current in rat sensory neurons: whole-cell and single-channel studies
John C. Lopshire,Grant D. Nicol +1 more
TL;DR: This article showed that exposure of the sensory neuron to either PGE2 or forskolin produced a large and transient increase in the mean channel activity (NPo) elicited by capsaicin, although the unitary conductance remained unaltered.
Journal ArticleDOI
Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes.
TL;DR: The results suggest that VR1 expression in keratinocytes may have a role in the inflammation that occurs secondary to epidermal damage or insult, and thus may function as a sensor for noxious cutaneous stimulation.
Journal ArticleDOI
Tumor Necrosis Factor Enhances the Capsaicin Sensitivity of Rat Sensory Neurons
TL;DR: The capacity of proinflammatory cytokines, such as TNFα and interleukin 1β, to modulate the sensitivity of isolated sensory neurons grown in culture to the excitatory chemical agent capsaicin was examined in this article.
Journal ArticleDOI
Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: On or off the trks?
Grant D. Nicol,Michael R. Vasko +1 more
TL;DR: Contrary to the general consensus, both NGF receptors appear to contribute to peripheral sensitization although whether they act independently or together remains to be determined.