PTP1B Inhibition and Antihyperglycemic Activity in the ob/ob Mouse Model of Novel 11-Arylbenzo[b]naphtho[2,3-d]furans and 11-Arylbenzo[b]naphtho[2,3-d]thiophenes

We report isomer-pure synthesis of thieno[2,3-f:5,4-f ']bis[1]benzothiophene and thieno[3,2-f:4,5-f ']bis[1]benzothiophene, the anti and syn isomers of a pentacyclic compound consisting of alternating thiophene and benzene rings. The optical and electrochemical properties of both are reported. In the anti isomer, the ribbonlike embedding of three thiophene units leads to a near-planar molecule with favorable pi-pi stacking behavior in the solid state as shown by X-ray crystal structure analysis.

Synthesis of the anti and syn isomers of thieno[f,f ']bis[1]benzothiophene. Comparison of the optical and electrochemical properties of the anti and syn isomers.

Benzylation via Tandem Grignard reaction —iodotrimethylsilane (TMSI) mediated reduction

The invention relates to tyrosine kinase inhibitors of bis-indolyl compounds of formula (I), to the medicaments containing said inhibitors and to their use in treating malignant and other diseases caused by pathological cell proliferation.

Indole derivatives and their use for the treatment of malignant and other diseases based on pathological cell proliferation

Isomer-pure thieno[3,2-f:4,5-f ‘]bis[1]benzothiophene (2, n = 2) has been synthesized in an efficient four step approach without column chromatography.

Greg Goodkin

Papers

REDUCTION OF HETEROCYCLIC ALCOHOLS WITH SODIUM BOROHYDRIDE-TRIFLUOROACETIC ACID. PREPARATION OF bis-HETEROCYCLIC METHANES