Gregory A Moyerbrailean

TL;DR: The results demonstrate that comprehensive catalogs of GxE interactions are indispensable to thoroughly annotate genes and bridge epidemiological and genome-wide association studies.

TL;DR: Infusing QL in introductory biology presents challenges, but the conclusion that it is feasible in the context of an existing course is supported, consistent with the goals of college biology education, and promotes students' development of important quantitative skills.

TL;DR: QuASAR, quantitative allele-specific analysis of reads, a novel statistical learning method for jointly detecting heterozygous genotypes and inferring ASE, is presented and validated with experimental data for which high-quality genotypes are available.

TL;DR: The results suggest that the effects of diets are likely to be habitat specific, and observations from the gut microbiome are not transferrable to the oral microbiome.

TL;DR: DNaseI footprinting data is integrated with sequence-based transcription factor (TF) motif models to predict the impact of a genetic variant on TF binding across 153 tissues and 1,372 TF motifs, revealing that the rich meta information provided by the tissue-specificity and the identity of the putative TF binding site being affected helps in identifying the underlying mechanism supporting the association.