G
Gregory E. Hannigan
Researcher at University of Toronto
Publications - 33
Citations - 3486
Gregory E. Hannigan is an academic researcher from University of Toronto. The author has contributed to research in topics: Integrin-linked kinase & Signal transduction. The author has an hindex of 24, co-authored 33 publications receiving 3365 citations. Previous affiliations of Gregory E. Hannigan include Hudson Institute & Hospital for Sick Children.
Papers
More filters
Journal ArticleDOI
Integrin-linked kinase: a cancer therapeutic target unique among its ILK
TL;DR: The recent findings of increased levels of ILK in various cancers, and that inhibition ofILK expression and activity is antitumorigenic, makes ILK an attractive target for cancer therapeutics.
Journal ArticleDOI
Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas.
Keith S. Hoek,David L. Rimm,Kenneth R. Williams,Hongyu Zhao,Stephan Ariyan,Aiping Lin,Harriet M. Kluger,Aaron Berger,Elaine Cheng,E. Sergio Trombetta,Terence Wu,Michio Niinobe,Kazuaki Yoshikawa,Gregory E. Hannigan,Ruth Halaban +14 more
TL;DR: A comprehensive view of changes in advanced melanoma relative to normal melanocytes is provided and new targets that can be used in assessing prognosis, staging, and therapy of melanoma patients are revealed.
Journal ArticleDOI
Integrin cytoplasmic interactions and bidirectional transmembrane signalling
TL;DR: New evidence suggests that, via interactions with focal adhesion kinase, the integrin cytoplasmic domains can coordinate actin cytoskeletal organization and responses to growth factors.
Journal ArticleDOI
Integrin-linked Kinase (ILK): A Regulator of Integrin and Growth-Factor Signalling
TL;DR: ILK appears to interact with and be influenced by a number of different signalling pathways, and this provides new routes for integrin-mediated signalling.
Journal ArticleDOI
Expression profiling reveals novel pathways in the transformation of Melanocytes to Melanomas.
Keith S. Hoek,David L. Rimm,Kenneth R. Williams,Hongyu Zhao,Stephan Ariyan,A. Lin,Harriet M. Kluger,Aaron Berger,E. Cheng,E. S. Trombetta,Terence Wu,Ruth Halaban,Michio Niinobe,Kazuaki Yoshikawa,Gregory E. Hannigan +14 more
TL;DR: A comprehensive view of changes in advanced melanoma relative to normal melanocytes is provided and new targets that can be used in assessing prognosis, staging, and therapy of melanoma patients are revealed.