G
Gregory G. Freund
Researcher at University of Illinois at Urbana–Champaign
Publications - 109
Citations - 10459
Gregory G. Freund is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Proinflammatory cytokine & Tyrosine phosphorylation. The author has an hindex of 38, co-authored 108 publications receiving 9347 citations. Previous affiliations of Gregory G. Freund include University of Rochester Medical Center & Urbana University.
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From inflammation to sickness and depression: when the immune system subjugates the brain
TL;DR: In response to a peripheral infection, innate immune cells produce pro-inflammatory cytokines that act on the brain to cause sickness behaviour, which can lead to an exacerbation of sickness and the development of symptoms of depression in vulnerable individuals.
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The health benefits of dietary fiber: Beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer
TL;DR: The accepted physiologic functions of DFs are described and their new potential immune-based actions are explored, including infection prevention and the improvement of mood and memory.
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Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system.
Jing Chen,Jessica B. Buchanan,Nathan L. Sparkman,Jonathan P. Godbout,Gregory G. Freund,Rodney W. Johnson +5 more
TL;DR: It is found that hippocampal processing is more easily disrupted in old animals than in younger ones when the peripheral innate immune system is stimulated, suggesting that aging can facilitate neurobehavioral complications associated with peripheral infections probably by allowing the over expression of inflammatory cytokines in brain areas that mediate cognitive processing.
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Interleukin-10 in the brain.
Klemen Strle,Jian Hua Zhou,Wen Hong Shen,Suzanne R. Broussard,Rodney W. Johnson,Gregory G. Freund,Robert Dantzer,Keith W. Kelley +7 more
TL;DR: The multiple functions of IL-10 in the brain will create new and intriguing vistas that will promote a better understanding of neurodegenerative diseases and could lead to development of innovative approaches for the use of antiinflammatory cytokines in major debilitating diseases of the CNS.
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IL-1 receptor 2 (IL-1R2) and its role in immune regulation.
TL;DR: The functional properties of IL-1R2 are detailed and its role in human disease is examined, which has been implicated in arthritis, endometriosis, organ transplantation, sepsis/sickness behavior, diabetes, atherosclerosis, autoimmune inner ear disease, Alzheimer's disease and ulcerative colitis.