G
Gregory L. Holmes
Researcher at Harvard University
Publications - 101
Citations - 7651
Gregory L. Holmes is an academic researcher from Harvard University. The author has contributed to research in topics: Epilepsy & Status epilepticus. The author has an hindex of 46, co-authored 101 publications receiving 7392 citations. Previous affiliations of Gregory L. Holmes include Boston Children's Hospital & Dartmouth College.
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Journal ArticleDOI
Developmental and Neurologic Status of Children after Heart Surgery with Hypothermic Circulatory Arrest or Low-Flow Cardiopulmonary Bypass
David C. Bellinger,Richard A. Jonas,Leonard Rappaport,David Wypij,Gil Wernovsky,Karl C.K. Kuban,Patrick D. Barnes,Gregory L. Holmes,Paul R. Hickey,R D Strand +9 more
TL;DR: The developmental and neurologic sequelae of these two strategies one year after heart surgery in infants were compared, with infants assigned to circulatory arrest having a lower mean score on the Psychomotor Development Index of the Bayley Scales of Infant Development.
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A Comparison of the Perioperative Neurologic Effects of Hypothermic Circulatory Arrest versus Low-Flow Cardiopulmonary Bypass in Infant Heart Surgery
Jane W. Newburger,Richard A. Jonas,Gil Wernovsky,David Wypij,Paul R. Hickey,Karl C.K. Kuban,David M. Farrell,Gregory L. Holmes,Sandra L. Helmers,Jules Constantinou,Enrique Carrazana,John K. Barlow,Amy Z. Walsh,Kristin C. Lucius,Jane Share,David L. Wessel,Frank L. Hanley,John E. Mayer,Aldo R. Castaneda,James H. Ware +19 more
TL;DR: This randomized, single-center trial compared the incidence of perioperative brain injury after deep hypothermia and support consisting predominantly of total circulatory arrest with the incidence after deep Hypothermic Circulatory arrest in a randomized,single- center trial.
Journal ArticleDOI
A multicenter study of the efficacy of the ketogenic diet
Eileen P.G. Vining,John M. Freeman,Karen Ballaban-Gil,Carol Camfield,Peter Camfield,Gregory L. Holmes,Shlomo Shinnar,Robert Shuman,Edwin Trevathan,James W. Wheless +9 more
TL;DR: The ketogenic diet is effective in substantially decreasing difficult-to-control seizures and can successfully be administered in a wide variety of settings.
Journal ArticleDOI
Kainic acid seizures in the developing brain : status epilepticus and spontaneous recurrent seizures
TL;DR: Data suggest that there are developmental differences in both acute and chronic responses to KA, with immature animals relatively protected from the long-term deleterious effects of this convulsant.
Journal ArticleDOI
Age‐Dependent Cognitive and Behavioral Deficits After Kainic Acid Seizures
Carl E. Stafstrom,Antonia Chronopoulos,Samuel J. Thurber,James L. Thompson,Gregory L. Holmes +4 more
TL;DR: Age-related behavioral and cognitive deficits after KA-induced seizures suggest Pubescents and adults had alterations in learning, memory, exploratory behavior, and response to handling, whereas younger animals had no obvious behavioral or cognitive deficits.