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Guanghui Zhang
Researcher at Southwest University
Publications - 11
Citations - 856
Guanghui Zhang is an academic researcher from Southwest University. The author has contributed to research in topics: Cancer research & Medicine. The author has an hindex of 2, co-authored 2 publications receiving 311 citations.
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Journal ArticleDOI
Targeting cancer stem cell pathways for cancer therapy
Liqun Yang,Pengfei Shi,Gaichao Zhao,Jie Xu,Wen Peng,Jiayi Zhang,Guanghui Zhang,Xiaowen Wang,Zhen Dong,Fei Chen,Hongjuan Cui +10 more
TL;DR: Molecules, vaccines, antibodies, and CAR-T (chimeric antigen receptor T cell) cells have been developed to specifically target CSCs, and some of these factors are already undergoing clinical trials.
Journal ArticleDOI
TRIP13 promotes the cell proliferation, migration and invasion of glioblastoma through the FBXW7/c-MYC axis.
Guanghui Zhang,Qingzong Zhu,Gang Fu,Jianbing Hou,Xiaosong Hu,Jiangjun Cao,Wen Peng,Xiaowen Wang,Fei Chen,Hongjuan Cui +9 more
TL;DR: The study indicated that the TRIP13/FBXW7/c-MYC pathway might provide a prospective therapeutic target in the treatment of GBM and indicated that TRip13 plays an oncogenic role in GBM.
Journal ArticleDOI
HECTD3 promotes gastric cancer progression by mediating the polyubiquitination of c-MYC
Guanghui Zhang,Qingzong Zhu,Xiaomin Yan,Mingxin Ci,Erhu Zhao,Jianbing Hou,Sicheng Wan,Muhan Lü,Hongjuan Cui +8 more
TL;DR: In this paper , the E3 ubiquitin ligase HECTD3 was found to be abnormally activated in gastric cancer, and the clinical prognosis database suggested that HECTd3 was strongly expressed in gastrial cancer.
Journal ArticleDOI
HECTD3 promotes gastric cancer progression by mediating the polyubiquitination of c-MYC
Guanghui Zhang,Qingzong Zhu,Xiaomin Yan,Mingxin Ci,Erhu Zhao,Jianbing Hou,Sicheng Wan,Muhan Lü,Hongjuan Cui +8 more
TL;DR: In this article , the E3 ubiquitin ligase HECTD3 was found to be abnormally activated in gastric cancer, and the clinical prognosis database suggested that HECTd3 was strongly expressed in gastrial cancer.
Journal ArticleDOI
HOXA3 and KDM6A cooperate in transcriptional control of aerobic glycolysis and glioblastoma progression.
Rui Yang,Guanghui Zhang,Zhen Dong,Shan Jin Wang,Yanping Li,Fu-Lin Lian,Xiaoran Liu,Haibin Li,Xiaonan Wei,Hongjuan Cui +9 more
TL;DR: These findings provide a novel molecular mechanism linking HOXA3-mediated transactivation and KDM6A-coupled H3K27 demethylation in regulating glucose metabolism and GBM progression.