Z
Zhen Dong
Researcher at Southwest University
Publications - 33
Citations - 1471
Zhen Dong is an academic researcher from Southwest University. The author has contributed to research in topics: Cell cycle checkpoint & Cell cycle. The author has an hindex of 14, co-authored 27 publications receiving 719 citations.
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Journal ArticleDOI
Targeting cancer stem cell pathways for cancer therapy
Liqun Yang,Pengfei Shi,Gaichao Zhao,Jie Xu,Wen Peng,Jiayi Zhang,Guanghui Zhang,Xiaowen Wang,Zhen Dong,Fei Chen,Hongjuan Cui +10 more
TL;DR: Molecules, vaccines, antibodies, and CAR-T (chimeric antigen receptor T cell) cells have been developed to specifically target CSCs, and some of these factors are already undergoing clinical trials.
Journal ArticleDOI
The roles of sirtuins family in cell metabolism during tumor development.
Shunqin Zhu,Zhen Dong,Xiao-Xue Ke,Jianbing Hou,Erhu Zhao,Kui Zhang,Feng Wang,Liqun Yang,Zhonghuai Xiang,Hongjuan Cui +9 more
TL;DR: This review highlights the major function and its mechanisms of sirtuins in cellular metabolic reprogramming, such as glucose metabolism including aerobic glycolysis, oxidative phosphorylation (OXPHOS)/tricarboxylic acid (TCA) cycle and glutamine metabolism; lipometabolism including fatty acid metabolism, cholesterol metabolism, ketone body metabolism and acetate metabolism; as well as leucine metabolism and the urea cycle in tumorigenesis and cancer development.
Journal ArticleDOI
The Emerging Roles of RNA Modifications in Glioblastoma.
Zhen Dong,Hongjuan Cui +1 more
TL;DR: This review summarizes the recent studies about RNA modifications, such as N6-methyladenosine (m6A), N6,2′O-dimethyladenosines (m 6Am), 5-methylcytosine (M5C), N1-methyl adenosine(m1A), inosine and pseudouridine (ψ) as well as the corresponding RMPs including the writers, erasers and readers that participate in the tumorigenesis
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Biological Functions and Molecular Mechanisms of Antibiotic Tigecycline in the Treatment of Cancers
TL;DR: Evidence indicates that antibiotic tigecycline is a promising drug for cancer treatment alone or in combination with other anticancer drugs.
Journal ArticleDOI
Demethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells.
Yuzu Zhao,Jiang He,Jun Li,Xingzhi Peng,Xianxing Wang,Zhen Dong,Erhu Zhao,Yaling Liu,Zonghui Wu,Hongjuan Cui +9 more
TL;DR: It is demonstrated that demethylzeylasteral has an anti-tumor property in melanoma cells and that it suppresses the expression of MCL1, a anti-apoptotic protein in BCL2 family that amplifies frequently in multiple human cancers.