Chemical modification of lignins: Towards biobased polymers

From a Novel

Biofilm formation in Staphylococcus implant infections. A review of molecular mechanisms and implications for biofilm-resistant materials.

Towards lignin-based functional materials in a sustainable world

https://www.cell.com/trends/biotechnology/pdf/S0167-7799(13)00030-9.pdf

Antibacterial surfaces: the quest for a new generation of biomaterials.

The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides

Antibacterial surfaces based on polymer brushes: investigation on the influence of brush properties on antimicrobial peptide immobilization and antimicrobial activity.

Synthesis of lignin nanofibers with ionic-responsive shells: water-expandable lignin-based nanofibrous mats.

Biomembrane Interactions Reveal the Mechanism of Action of Surface-Immobilized Host Defense IDR-1010 Peptide

Development of advanced functional materials from naturally abundant polymers such as cellulose are of significant importance. Of particular interest is embedding antibacterial functionality to cellulose materials to make permanent antibacterial materials and devices. In the present research, a “clickable” quaternary ammonium compound, N-(2-ethoxy-2-oxoethyl)-N,N-dimethylprop-2yn-1-aminium bromide (EdMPABr) was synthesized via a simple reaction with nearly stoichiometric yield and well characterized with 1D (1H, 13C) and 2D (COSY, HSQC) NMR and ATR-FTIR. EdMPABr can be covalently bonded to many molecules containing an azido group to form non-leaching antibacterial materials via the simple Cu(I)-catalyzed alkyne-azide [2 + 3] cycloaddition reaction. As an example, EdMPABr was attached to our previously reported 3-O-azidopropoxypoly(ethylene glycol)-2,6-di-O-thexyldimethylsilyl cellulose (3-N3PEG-2,6-TDMS cellulose, DS = 0.54 at C3 determined by 1H NMR). Significant antibacterial activity of the synthesized 3-O-quaternary ammonium-2,6-di-O-thexyldimethylsilyl cellulose (3-QA-2,6-TDMS cellulose, DS = 0.30 at C3 determined by using N content from elemental analysis) was confirmed by testing against the representative bacteria Escherichia coli. By linking the EdMPABr to the honeycomb film of 3-N3PEG-2,6-TDMS cellulose, the formed honeycomb film exhibited both antibacterial and antifouling properties. This research provides a simple and robust route towards the development of permanent antibacterial materials and biomedical devices.

Synthesis of antibacterial cellulose materials using a “clickable” quaternary ammonium compound

Guangzheng Gao

Papers

The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides

Antibacterial surfaces based on polymer brushes: investigation on the influence of brush properties on antimicrobial peptide immobilization and antimicrobial activity.

Synthesis of lignin nanofibers with ionic-responsive shells: water-expandable lignin-based nanofibrous mats.

Biomembrane Interactions Reveal the Mechanism of Action of Surface-Immobilized Host Defense IDR-1010 Peptide

Synthesis of antibacterial cellulose materials using a “clickable” quaternary ammonium compound