G
Guanhua Du
Researcher at Peking Union Medical College
Publications - 664
Citations - 14962
Guanhua Du is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 52, co-authored 591 publications receiving 10878 citations. Previous affiliations of Guanhua Du include Shanxi University & Guangdong Pharmaceutical University.
Papers
More filters
Journal ArticleDOI
Structure–activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities
TL;DR: The SAR analysis of flavonoids on influenza virus NAs revealed that for good inhibitory effect, the 4'-OH, 7-OH, C4O, and C2C3 functionalities were essential, and the presence of a glycosylation group greatly reduced NA inhibition.
Journal ArticleDOI
Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro.
TL;DR: In in vitro experiments, baicalein (0.5, 5 microg/mL) could significantly ameliorate the 6-OHDA-induced SH-SY5Y cell apoptosis, and also promote neurite outgrowth of PC12 cell, and the neuroprotective action of baicalsein was coincident with an attenuated astroglial response within the substantia nigra.
Journal ArticleDOI
Cardioprotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats.
TL;DR: It is suggested that salvianolic acid A possessing antioxidant activity has a significant protective effect against isoproterenol-induced myocardial infarction and mitochondrial respiratory function.
Journal ArticleDOI
SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice
Li Li,Hui-Na Zhang,Hou-Zao Chen,Peng Gao,Lihua Zhu,Hongliang Li,Xiang Lv,Qing-Jun Zhang,Ran Zhang,Zhao V. Wang,Zhi-Gang She,Yu-Sheng Wei,Guanhua Du,De-Pei Liu,Chih-Chuan Liang +14 more
TL;DR: The inhibitory effect of SIRT1 is demonstrated on the VSMC proliferation and migration that underlie neointima formation and implicate Sirtuin 1 as a potential target for intervention in vascular diseases.
Journal ArticleDOI
Effect of salvianolic acids from Radix Salviae miltiorrhizae on regional cerebral blood flow and platelet aggregation in rats.
TL;DR: It is suggested that salvianolic acids could improve rCBF in the ischemic hemisphere and inhibit platelet aggregation in rats and in vitro and in vivo.