G
Guidong Yao
Researcher at Zhengzhou University
Publications - 40
Citations - 997
Guidong Yao is an academic researcher from Zhengzhou University. The author has contributed to research in topics: Embryo & Blastocyst. The author has an hindex of 12, co-authored 36 publications receiving 599 citations. Previous affiliations of Guidong Yao include Stanford University.
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Journal ArticleDOI
Chromatin analysis in human early development reveals epigenetic transition during ZGA
Jingyi Wu,Jingyi Wu,Jingyi Wu,Jiawei Xu,Bofeng Liu,Guidong Yao,Peizhe Wang,Zili Lin,Bo Huang,Xuepeng Wang,Tong Li,Senlin Shi,Nan Zhang,Fuyu Duan,Jia Ming,Xiangyang Zhang,Wenbin Niu,Wenyan Song,Haixia Jin,Yihong Guo,Shanjun Dai,Linli Hu,Lanlan Fang,Qiujun Wang,Yuanyuan Li,Wei Li,Jie Na,Wei Xie,Yingpu Sun +28 more
TL;DR: By applying an improved assay for transposase-accessible chromatin with high-throughput sequencing to human early embryos, distinct accessible chromatin landscapes are found, revealing a marked epigenetic transition during zygotic genome activation and putative regulatory elements wiring human early development.
Journal ArticleDOI
In Vitro Activation of Follicles and Fresh Tissue Auto-transplantation in Primary Ovarian Insufficiency Patients.
Jun Zhai,Guidong Yao,Fangli Dong,Zhiqin Bu,Yuan Cheng,Yorino Sato,Linli Hu,Yingying Zhang,Jing-Yuan Wang,Shanjun Dai,Jing Li,Jing Sun,Aaron J. W. Hsueh,Kazuhiro Kawamura,Yingpu Sun +14 more
TL;DR: IVA technology can effectively activate residual follicles in some patients with POI and allow them to conceive their own genetic offspring and may also be useful for treating patients with ovarian dysfunction including aging women and cancer survivors.
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Resetting histone modifications during human parental-to-zygotic transition
Weikun Xia,Jiawei Xu,Guang Yu,Guidong Yao,Kai Xu,Xueshan Ma,Nan Zhang,Bofeng Liu,Tong Li,Zili Lin,Xia Chen,Lijia Li,Qiujun Wang,Dayuan Shi,Senlin Shi,Yile Zhang,Wenyan Song,Haixia Jin,Linli Hu,Zhiqin Bu,Yang Wang,Jie Na,Wei Xie,Yingpu Sun +23 more
TL;DR: By combining chromatin and transcriptome maps, the data unveil a priming phase connecting human parental-to-zygotic epigenetic transition and transcription circuitry and asymmetric H3K27me3 patterning during early lineage specification.
Journal ArticleDOI
Melatonin attenuates postovulatory oocyte dysfunction by regulating SIRT1 expression.
Qingling Yang,Shanjun Dai,Xiaoyan Luo,Jing Zhu,Fangyuan Li,Jinhao Liu,Guidong Yao,Yingpu Sun +7 more
TL;DR: The data strongly indicate that melatonin delays postovulatory mouse oocyte aging via a SIRT1-MnSOD-dependent pathway, which may provide a molecular mechanism support for the further application of melatonin in the assisted reproductive technology field.
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Comparison of differences in development potentials between frozen-thawed D5 and D6 blastocysts and their relationship with pregnancy outcomes.
TL;DR: High-quality D6 blastocysts in frozen-thawed cycles had similar developmental potential and pregnancy outcomes compared to those of high- quality D5 blastocysta cycles, and the quality of the blastocyst was an important factor that affected the pregnancy outcomes of the frozen- Thawed cycles.