Showing papers by "Gülin Öz published in 2005"
TL;DR: The progression of adrenoleukodystrophy, as well as effectiveness of its treatment, can be assessed with high precision using high field 1H magnetic resonance spectroscopy in individual patients without the need for sedation.
Abstract: Early detection of white matter lesions in childhood-onset cerebral adrenoleukodystrophy (ALD) is important as hematopoietic cell transplantation (HCT), currently the only effective treatment, is beneficial only if performed early in the disease course.
86 citations
TL;DR: A pulse sequence that accomplishes the spatial localization of1H-decoupled13C NMR signals on a whole-body scanner within the Food and Drug Administration guidelines for specific absorption rates was designed.
Abstract: Nuclear magnetic resonance (NMR) signals with short T1 and T2, such as the 13C signal of glycogen, are difficult to localize in three dimensions without major signal loss A pulse sequence that accomplishes the spatial localization of 1H-decoupled 13C NMR signals on a whole-body scanner within the Food and Drug Administration guidelines for specific absorption rates was designed The method uses an optimized three-dimensional outer volume suppression scheme combined with one-dimensional image-selected in vivo spectroscopy and surface coil detection The localization performance of the sequence was validated at 4 T with double chambered phantoms and 13C magnetic resonance imaging Localized 13C spectra were acquired from human brain and muscle © Springer-Verlag 2005
10 citations