G
Gunter Karig
Researcher at Bayer
Publications - 25
Citations - 180
Gunter Karig is an academic researcher from Bayer. The author has contributed to research in topics: Oxindole & Aniline. The author has an hindex of 7, co-authored 25 publications receiving 168 citations. Previous affiliations of Gunter Karig include Bayer Corporation.
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Patent
4-(pyridin-3-yl)-2-(pyridin-2-yl)-1,2-dihydro-3h-pyrazol-3-one derivatives as specific hif-prolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases
Flamme Ingo,Erguden Jens-Kerim,Felix Oehme,Kai Thede,Gunter Karig,Alexander Kuhl,Hanno Wild,Joachim Schuhmacher,Kolkhof Peter,Baerfacker Lars,Huetter Joachim +10 more
TL;DR: In this paper, the authors present an application related to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases, and their use in the preparation of medicaments for treatment or prevention of diseases.
Journal ArticleDOI
Discovery of Molidustat (BAY 85-3934): A Small-Molecule Oral HIF-Prolyl Hydroxylase (HIF-PH) Inhibitor for the Treatment of Renal Anemia.
Hartmut Beck,Mario Jeske,Kai Dr. Thede,Friederike Stoll,Ingo Flamme,Metin Akbaba,Jens-Kerim Ergüden,Gunter Karig,Jörg Keldenich,Felix Oehme,Hans-Christian Militzer,Ingo Hartung,Uwe Thuss +12 more
TL;DR: The discovery, synthesis, structure–activity relationship (SAR), and proposed binding mode of novel 2,4‐diheteroaryl‐1,2‐dihydro‐3H‐pyrazol‐3‐ones as orally bioavailable HIF‐PH inhibitors for the treatment of anemia are described.
Patent
Substituted Phenylaminothiazoles and Use Thereof
Erguden Jens-Kerim,Gunter Karig,Rosentreter Ulrich,Albrecht Barbara,Henninger Kerstin,Huetter Joachim,Diedrichs Nicole,Nell Peter,Arndt Sabine,Hübsch Walter,Andreas Knorr,Karl-Heinz Schlemmer,Brohm Dirk +12 more
TL;DR: The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases, and to the use for preparing medicaments for treating or preventing hypertension and other cardiovascular disorders.
Patent
Substituted 1,2,4-triazin-5(2h)-ones
Martin Hendrix,Claudia Hirth-Dietrich,Gunter Karig,Dagmar Karthaus,Martin Raabe,Olaf Weber,Siegfried Zaiss,Katja Zimmermann +7 more
TL;DR: The 1,2,4-triazin-5(2H)-one was used for treating and/or preventing chronic inflammatory diseases, such as rheumatoid diseases and cardiovascular diseases.
Patent
3-arylalkyl-substituted and 3-heteroarylalkyl-substituted-1,2,4-triazin-5(2h)-ones
Martin Hendrix,Katja Zimmermann,Claudia Hirth-Dietrich,Gunter Karig,Dagmar Karthaus,Martin Raabe,Olaf Weber,Siegfried Zaiss +7 more
TL;DR: In this paper, a method for the production of 3-arylalkyl-substituted and 3-hetero-aryl-alkyl -substitized 1,2,4-triazin-5(2H)-one is described.