G
Guoyi Li
Researcher at Jilin University
Publications - 12
Citations - 756
Guoyi Li is an academic researcher from Jilin University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 4, co-authored 4 publications receiving 676 citations.
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Journal ArticleDOI
SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson's disease.
Hongrong Xie,Lin-sen Hu,Guoyi Li +2 more
TL;DR: Evaluating the human neuroblastoma SH-SY5Y cell line as an in vitro model of dopaminergic (DAergic) neurons for Parkinson's disease (PD) research and the effect of differentiation on this cell model found some differentiating agents afford SH- SY5Y cells with more potential for studying neurotoxicity and neuroprotection and are thus more relevant to experimental PD research.
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HDAC6 α-tubulin deacetylase: a potential therapeutic target in neurodegenerative diseases.
TL;DR: The research of the role played by HDAC6 in the regulation of tubulin modification and aggresome formation is reviewed and the specific inhibitors ofHDAC6 are summarized.
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Proteomics analysis of MPP+-induced apoptosis in SH-SY5Y cells
Hongrong Xie,Ming Chang,Xinyu Hu,Danping Wang,Mingxiu Tian,Guoyi Li,Huiyi Jiang,Ying Wang,Zhong Dong,Yuhua Zhang,Linsen Hu +10 more
TL;DR: The functional roles of these three proteins collectively indicate that multiple mechanisms are pertinent in the underlying pathogenesis of Parkinson’s disease (PD), such as apoptosis, calcium homeostasis, and DNA insults.
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Proteomics analysis of methylglyoxal-induced neurotoxic effects in SH-SY5Y cells.
TL;DR: The results suggest that multiple pathways are potentially involved in MG‐induced neuron death, including actin, immunoglobulin lambda light chain and protein phosphatase 2, which are noteworthy given their functional roles in AD pathogenesis.
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Molecular Mechanisms of Epileptic Encephalopathy Caused by KCNMA1 Loss-of-Function Mutations
Yu-Hong Yao,Dongxiao Qu,Xiaoping Jing,Yuxiang Jia,Qi Zhong,Limin Zhuo,Xingxing Chen,Guoyi Li,Lele Tang,Yudan Zhu,Yonghua Ji,Zhiping Li,Jie Tao +12 more
TL;DR: The study indicated that newly-found point E155Q resulted in a novel loss-of-function variant and the dysregulation of gene expression, especially astrocyte activation, neuroinflammation and autophagy, might be the molecular mechanism of BK-LOF meditated epilepsy.