G
Guy Simonnet
Researcher at University of Bordeaux
Publications - 116
Citations - 5749
Guy Simonnet is an academic researcher from University of Bordeaux. The author has contributed to research in topics: Hyperalgesia & Neuropeptide FF. The author has an hindex of 38, co-authored 116 publications receiving 5566 citations. Previous affiliations of Guy Simonnet include Université Bordeaux Segalen & French Institute of Health and Medical Research.
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Journal ArticleDOI
Long-lasting Hyperalgesia Induced by Fentanyl in Rats: Preventive Effect of Ketamine
TL;DR: Fentanyl activates NMDA pain facilitatory processes, which oppose analgesia and lead to long-lasting enhancement in pain sensitivity, and the higher the fentanyl dose used, the more pronounced was the fentanyl-induced hyperalgesia.
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Opioid-induced hyperalgesia: abnormal or normal pain?
Guy Simonnet,Cyril Rivat +1 more
TL;DR: In this article, the authors examined experimental evidences which indicate that exogenous opioids simultaneously activate both inhibitory and facilitatory pain systems leading to a longlasting enhancement in pain sensitivity after analgesia.
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The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance.
Jean-Paul Laulin,Pierre Maurette,Jean-Benoît Corcuff,Cyril Rivat,Marcel Chauvin,Guy Simonnet +5 more
TL;DR: The results indicate that sustained NMDA-receptor blocking could be a fruitful therapy for improving postoperative morphine effectiveness and that sustained ketamine pretreatment had no analgesic effect per se at the dose used herein.
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Progressive enhancement of delayed hyperalgesia induced by repeated heroin administration: a sensitization process.
TL;DR: It is shown that both magnitude and duration of heroin-induced delayed hyperalgesia increase with intermittent heroin administrations, leading to an apparent decrease in the analgesic effectiveness of a given heroin dose, suggesting a neuroadaptive process in which NMDA systems play a critical role.
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RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia
Frédéric Simonin,Martine Schmitt,Jean-Paul Laulin,Emilie Laboureyras,Jack H. Jhamandas,David MacTavish,Audrey Matifas,Catherine Mollereau,Patrick Laurent,Marc Parmentier,Brigitte L. Kieffer,Jean-Jacques Bourguignon,Guy Simonnet +12 more
TL;DR: The discovery of a potent and selective NPFF receptor antagonist, RF9, that can be administered systemically and indicate that NPFF receptors are part of a bona fide antiopioid system and that selective antagonists of these receptors could represent useful therapeutic agents for improving the efficacy of opioids in chronic pain treatment.