Oxidative Stress, Inflammation, and Cancer: How Are They Linked?

EAU–ESTRO–SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent

https://www.europeanurology.com/article/S0302-2838(13)01040-3/pdf/eau-guidelines-on-prostate-cancer-part-1-screening-diagnosis-and-local-treatment-with-curative-intent-update-2013

EAU Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent—Update 2013

Task Group 101 of the AAPM has prepared this report for medical physicists, clinicians, and therapists in order to outline the best practice guidelines for the external-beam radiation therapy technique referred to as stereotactic body radiation therapy (SBRT). The task group report includes a review of the literature to identify reported clinical findings and expected outcomes for this treatment modality. Information is provided for establishing a SBRT program, including protocols, equipment, resources, and QA procedures. Additionally, suggestions for developing consistent documentation for prescribing, reporting, and recording SBRT treatment delivery is provided.

https://aapm.onlinelibrary.wiley.com/doi/pdf/10.1118/1.3438081

Stereotactic body radiation therapy: The report of AAPM Task Group 101

Ductal carcinoma in situ (DCIS) of the breast represents a heterogeneous group of neoplastic lesions in the breast ducts. The goal for management of DCIS is to prevent the development of invasive breast cancer. This manuscript focuses on the NCCN Guidelines Panel recommendations for the workup, primary treatment, risk reduction strategies, and surveillance specific to DCIS.

https://www.unitypoint.org/desmoines/filesimages/Cancer%20Education/Oncology%20Nursing%20Conference/2015/2014%20NCCN%20Clin%20Pract%20Guidelines%20Male%20Sex%20Dysf.pdf

Clinical practice guidelines in oncology

Background The combination of radiotherapy plus long-term medical suppression of androgens (≥2 years) improves overall survival in patients with locally advanced prostate cancer We compared the use of radiotherapy plus short-term androgen suppression with the use of radiotherapy plus long-term androgen suppression in the treatment of locally advanced prostate cancer Methods We randomly assigned patients with locally advanced prostate cancer who had received external-beam radiotherapy plus 6 months of androgen suppression to two groups, one to receive no further treatment (short-term suppression) and the other to receive 25 years of further treatment with a luteinizing hormone–releasing hormone agonist (long-term suppression) An outcome of noninferiority of short-term androgen suppression as compared with long-term suppression required a hazard ratio of more than 135 for overall survival, with a one-sided alpha level of 005 An interim analysis showed futility, and the results are presented with an a

https://www.nejm.org/doi/pdf/10.1056/NEJMoa0810095

Duration of androgen suppression in the treatment of prostate cancer.

The limited ability to control for the location of a tumour compromises the accuracy with which radiation can be delivered to tumour-bearing tissue. The resultant requirement for larger treatment volumes to accommodate target uncertainty restricts the radiation dose because more surrounding normal tissue is exposed. With image-guided radiotherapy (IGRT) these volumes can be optimized and tumoricidal doses can be delivered, achieving maximal tumour control with minimal complications. Moreover, with the ability of high-precision dose delivery and real-time knowledge of the target volume location, IGRT has initiated the exploration of new indications for radiotherapy, some of which were previously considered infeasible.

Innovations in image-guided radiotherapy.

Quality assurance of a system for improved target localization and patient set-up that combines real-time infrared tracking and stereoscopic X-ray imaging.

Adjuvant radiotherapy for breast cancer significantly improves overall survival: the missing link.

Nature Reviews Cancer 7, 949– 960 (2007) There is an error in Box 1 of this article on page 951. The formula for the volume of a sphere is incorrectly shown; it should read 4/3 π r3.

/pdf/erratum-innovations-in-image-guided-radiotherapy-4303jaocz6.pdf

Guy Soete

Papers

Duration of androgen suppression in the treatment of prostate cancer.

Innovations in image-guided radiotherapy.

Quality assurance of a system for improved target localization and patient set-up that combines real-time infrared tracking and stereoscopic X-ray imaging.

Adjuvant radiotherapy for breast cancer significantly improves overall survival: the missing link.

Erratum: Innovations in image-guided radiotherapy