G
Guy Vergnault
Publications - 51
Citations - 819
Guy Vergnault is an academic researcher. The author has contributed to research in topics: Controlled release & Dosage form. The author has an hindex of 13, co-authored 51 publications receiving 798 citations.
Papers
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Journal ArticleDOI
Pharmacokinetic evaluation of oral fenofibrate nanosuspensions and SLN in comparison to conventional suspensions of micronized drug.
Abeer Hanafy,Hilde Spahn-Langguth,Guy Vergnault,Pascal Grenier,M Tubic Grozdanis,T. Lenhardt,Peter Langguth +6 more
TL;DR: Nanosuspensions may be a suitable delivery system to improve the bioavailability of drugs with low water solubility and may help to overcome these problems by increasing saturation solubilities and dissolution velocity.
Journal ArticleDOI
Nanosuspension Formulations for Low-Soluble Drugs: Pharmacokinetic Evaluation Using Spironolactone as Model Compound
Peter Langguth,Abeer Hanafy,D. Frenzel,Pascal Grenier,Alain Nhamias,T. Ohlig,Guy Vergnault,Hilde Spahn-Langguth +7 more
TL;DR: Improvement in drug solubility in the intestine as well as in dissolution rate of spironolactone are the most likely mechanisms responsible for the observed effect, although additional mechanisms such as permeability enhancement may also be involved.
Patent
Pharmaceutical tablet, completely coated, for controlled release of active principles that present problems of bio-availability linked to gastro-intestinal absorption
TL;DR: In this article, a particular type of pharmaceutical tablet, for oral use, which is formed by one or more layers, and is specifically designed for controlled release of active principles that present problems of bio-availability linked to absorption in the gastro-intestinal tract, and in particular active principles present an erratic and unpredictable absorption linked to the presence or absence of food at the level of the stomach and/or of the first portion of the small intestine, is described.
Patent
Tablet with controlled release of alfuzosine chlorydrate
Lauretta Maggi,Ubaldo Conte,Grenier Pascal,Guy Vergnault,Dufour Alain,Jarreau Francois Xavier,Clemence Rauch-Desanti +6 more
TL;DR: In this paper, a pharmaceutical tablet for oral administration, for the controlled release of alfuzosine chlorhydrate at the proximal segments of the gastrointestinal tract, characterised in that it consists of a first layer, capable of swelling noticeably and rapidly in contact with aqueous biological liquids, said layer being produced by a mixture or a granule containing hydrophilic polymers constituting 5.0 to 90 % and preferably 10 to 85 % of the layer weight.
Patent
Hydrophilic / lipophilic polymeric matrix dosage formulation
TL;DR: An oral dosage form comprising a pharmaceutical tablet of one or more layers, one of which carries a biologically active substance; the formulation of said tablet includes different percentages of hydrophilic and lipophilic polymeric materials, and adjuvant substances.