G
Gwo-Jyh Chang
Researcher at Chang Gung University
Publications - 28
Citations - 418
Gwo-Jyh Chang is an academic researcher from Chang Gung University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 10, co-authored 20 publications receiving 286 citations.
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Journal ArticleDOI
Transforming growth factor-β and oxidative stress mediate tachycardia-induced cellular remodelling in cultured atrial-derived myocytes
Yung-Hsin Yeh,Chi-Tai Kuo,Ting-Hsiang Chan,Gwo-Jyh Chang,Xiao-Yan Qi,Feng-Chun Tsai,Stanley Nattel,Wei-Jan Chen +7 more
TL;DR: Investigation of the role of oxidative stress and related factors in tachycardia-induced atrial structural remodelling finds rapid activation in atrial myocytes promotes myofibril degradation through autocrine/paracrine TGF-β signalling and increased oxidative stress.
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Atrial fibrillation and its arrhythmogenesis associated with insulin resistance
Yi-Hsin Chan,Yi-Hsin Chan,Gwo-Jyh Chang,Ying-Ju Lai,Wei-Jan Chen,Wei-Jan Chen,Shang-Hung Chang,Shang-Hung Chang,Li-Man Hung,Chi-Tai Kuo,Chi-Tai Kuo,Yung-Hsin Yeh,Yung-Hsin Yeh +12 more
TL;DR: IR engenders both atrial structural remodeling and abnormal intracellular calcium homeostasis, contributing to increased AF susceptibility, and the inhibition of CaMKII may be a potential therapeutic target for AF in insulin resistance.
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Nicotinamide adenine dinucleotide phosphate oxidase 4 mediates the differential responsiveness of atrial versus ventricular fibroblasts to transforming growth factor-β.
TL;DR: In this paper, the authors compared the response of cultured atrial versus ventricular fibroblasts with transforming growth factor-β (TGF-β), a key mediator of myocardial fibrosis.
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Molecular characterization of thyroid hormone-inhibited atrial L-type calcium channel expression: implication for atrial fibrillation in hyperthyroidism
TL;DR: Thyroid hormone-induced TR binding of CREB inhibits CREB activity and LCC current expression, which may contribute to AF, and co-immunoprecipitation documented an increased binding of TR with CREB after T3 treatment.
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Protective role of heme oxygenase-1 in atrial remodeling
TL;DR: A negative-feedback regulation of HO-1 in activated atrial myocytes and fibroblasts may provide protection against AF-related remodeling and AF development.