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H. B. Woodruff
Researcher at Merck & Co.
Publications - 11
Citations - 1465
H. B. Woodruff is an academic researcher from Merck & Co.. The author has contributed to research in topics: Cefoxitin & Streptomyces. The author has an hindex of 9, co-authored 11 publications receiving 1403 citations.
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Journal ArticleDOI
Phosphonomycin, a New Antibiotic Produced by Strains of Streptomyces
David Hendlin,Edward O. Stapley,M. Jackson,Hyman Wallick,Miller Ak,Frank J. Wolf,Thomas W. Miller,Louis Chaiet,Frederick M. Kahan,Eldon L. Foltz,H. B. Woodruff,J.M. Mata,Sebastian Hernandez,Sagrario Mochales +13 more
TL;DR: Phosphonomycin is a newly discovered antibiotic produced by streptomycetes that is effective, when administered by the oral route, to mice infected with Gram-positive or Gram-negative microorganisms.
Journal ArticleDOI
Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties.
Jean S. Kahan,Frederick M. Kahan,Robert T. Goegelman,Sara A. Currie,M. Jackson,Edward O. Stapley,Thomas W. Miller,Miller Ak,David Hendlin,Sagrario Mochales,Sebastian Hernandez,H. B. Woodruff,Jerome Birnbaum +12 more
TL;DR: A new beta-lactam antibiotic, named thienamycin, was discovered in culture broths of Streptomyces MA4297, and subsequently determined to be a hitherto unrecognized species, is designated StrePTomyces cattleya (NRRL 8057).
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Cephamycins, a New Family of β-Lactam Antibiotics I. Production by Actinomycetes, Including Streptomyces lactamdurans sp. n
Edward O. Stapley,M. Jackson,Sebastian Hernandez,Sheldon B. Zimmerman,Sara A. Currie,Sagrario Mochales,Mata Justo M,H. B. Woodruff,David Hendlin +8 more
TL;DR: A number of actinomycetes isolated from soil were found to produce one or more members of a new family of antibiotics, the cephamycins, which are structurally related to cephalosporin C.
Journal ArticleDOI
Fosfomycin: Laboratory studies.
H. B. Woodruff,J.M. Mata,Sebastian Hernandez,Sagrario Mochales,Antonio Ernesto Gómez Rodríguez,E. O. Stapley,Hyman Wallick,Miller Ak,D. Hendlin +8 more
TL;DR: Fosfomycin, a nontoxic broad-spectrum antibiotic, different in structure from all previously described antibiotics, acts selectively by inhibiting cell wall formation and has favorable pharmacologic characteristics.
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Cefoxitin and Cephamycins: Microbiological Studies
TL;DR: The therapeutic effectiveness of cefoxitin in experimental infections in mice confirms the excellent characteristics of this semisynthetic cephamycin and indicates that it should be a very valuable agent for treatment of bacterial infections.