H
H C Lane
Researcher at National Institutes of Health
Publications - 69
Citations - 13842
H C Lane is an academic researcher from National Institutes of Health. The author has contributed to research in topics: T cell & Virus. The author has an hindex of 44, co-authored 69 publications receiving 13313 citations.
Papers
More filters
Journal ArticleDOI
Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome.
TL;DR: The scope of immune dysfunction in the acquired immunodeficiency syndrome involves B cells as well as T cells, and it is concluded that the manifestations of B-cell hyperreactivity, such as hypergammaglobulinemia, seen in these patients are due to an in vivo polyclonal activation of B cells.
Journal ArticleDOI
A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics.
Sabue Mulangu,Lori E. Dodd,Richard T. Davey,Tshiani Mbaya O,Proschan M,Mukadi D,Lusakibanza Manzo M,Didier Nzolo,Tshomba Oloma A,Ibanda A,Ali R,Sheick Oumar Coulibaly,Adam C. Levine,Rebecca F. Grais,Diaz J,H C Lane,Muyembe-Tamfum Jj,Sivahera B,Camara M,Kojan R,Walker R,Bonnie Dighero-Kemp,Huyen Cao,Mukumbayi P,Mbala-Kingebeni P,Ahuka S,Albert S,Tyler Bonnett,Ian Crozier,Duvenhage M,Proffitt C,Teitelbaum M,Moench T,Aboulhab J,Kevin Barrett,Cahill K,Cone K,Eckes R,Lisa E. Hensley,Herpin B,Elizabeth S. Higgs,Ledgerwood J,Pierson J,Smolskis M,Sow Y,Tierney J,Sivapalasingam S,Holman W,Gettinger N,Vallée D,Nordwall J +50 more
TL;DR: A shorter duration of symptoms before admission and lower baseline values for viral load and for serum creatinine and aminotransferase levels each correlated with improved survival, and both MAb114 and REGN-EB3 were superior to ZMapp in reducing mortality from EVD.
Journal ArticleDOI
Acquired Immunodeficiency Syndrome: Epidemiologic, Clinical, Immunologic, and Therapeutic Considerations
Anthony S. Fauci,Abe M. Macher,Dan L. Longo,H C Lane,Alain H. Rook,Henry Masur,Edward P. Gelmann +6 more
TL;DR: The acquired immunodeficiency syndrome is a new disease whose cause is unknown but is almost surely due to a transmissible agent, most likely a virus.
Journal ArticleDOI
The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4
Steven M. Schnittman,M. C. Psallidopoulos,H C Lane,L. M. Thompson,M Baseler,F. E. Massari,Cecil H. Fox,N P Salzman,Anthony S. Fauci +8 more
TL;DR: High level of infection with HIV-1 may be the primary cause for the progressive decline in number and function of CD4+ T cells in patients with AIDS.
Journal ArticleDOI
Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. Evidence for a selective defect in soluble antigen recognition.
TL;DR: The lymphocytes of patients with AIDS, although capable of undergoing a normal degree of blast transformation and lymphokine production after mitogenic stimulation, have an intrinsic defect in their ability to recognize and respond to soluble antigen.