On-line sample preconcentration in capillary electrophoresis: Fundamentals and applications

In this paper, capillary electrophoresis in clinical and forensic analysis is reviewed on the basis of the literature of 1999, 2000 and the first papers in 2001. An overview of progress and relevant examples for each major field of application, namely (i) analysis of drug seizures, explosives residues, gunshot residues and inks, (ii) monitoring of drugs, endogenous small molecules and ions in biofluids and tissues, (iii) general screening for serum proteins and analysis of specific proteins (carbohydrate deficient transferrin, α1-antitrypsin, lipoproteins and hemoglobins) in biological fluids, and (iv) analysis of nucleic acids and oligonucleotides in biological samples, including oligonucleotide therapeutics, are presented.

Advances of capillary electrophoresis in clinical and forensic analysis (1999–2000)

Textile fibers are a key form of trace evidence, and the ability to reliably associate or discriminate them is crucial for forensic scientists worldwide. While microscopic and instrumental analysis can be used to determine the composition of the fiber itself, additional specificity is gained by examining fiber color. This is particularly important when the bulk composition of the fiber is relatively uninformative, as it is with cotton, wool, or other natural fibers. Such analyses pose several problems, including extremely small sample sizes, the desire for nondestructive techniques, and the vast complexity of modern dye compositions. This review will focus on more recent methods for comparing fiber color by using chromatography, spectroscopy, and mass spectrometry. The increasing use of multivariate statistics and other data analysis techniques for the differentiation of spectra from dyed fibers will also be discussed.

Forensic analysis of dyed textile fibers

Simultaneous determination of inorganic anions and organic acids in amine solutions for sour gas treatment by capillary electrophoresis with indirect UV detection.

Analysis of carboxylic acid metabolites from the tricarboxylic acid cycle in Bacillus subtilis cell extract by capillary electrophoresis using an indirect photometric detection method.

H. Logtenberg

Papers

Analysis of single textile fibres by sample-induced isotachophoresis – micellar electrokinetic capillary chromatography

Low-molecular-mass anion screening for forensic environmental analyses by capillary zone electrophoresis with indirect UV detection