Dimethyl 5-amino-2-hydroxy-4,6-dimethylisophthalate and dimethyl 5-amino-2-hydroxy-4,6-dimethylisophthalate were obtained in the free form for the first time. The products were sulfonylated with p-toluenesulfonyl to obtain previously unknown dialkyl 5-(4-toluenesulfonamido)-2-hydroxy-4,6-dimethylisophthalates. The use of p-acetamidobenzenesulfonyl chloride as the sulfonylating agent in this reaction led to the formation of dialkyl 5-(4-acetamidobenzenesulfonamido)-2-hydroxy-4,6-dimethyl isophthalates. The synthesized sulfonamide derivatives are of interest as potentially biologically active compounds. The structure of all the obtained compounds was proved using IR and NMR spectroscopy and mass spectrometry.

Synthesis of Dialkyl 5-Amino-2-hydroxy-4,6-dimethylisophthalates and Their Sulfonylation

Phenols with Two or Several Benzoyl Groups (Class of METHANONES)

[5-Aminoacetamido-4,6-dimethyl-2-hydroxy-isophthalic acid diethyl ester: synthesis and investigation of antiarrhythmic properties. 92. Studies of pyran derivatives].

H.-P. Leister

Papers

[5-Aminoacetamido-4,6-dimethyl-2-hydroxy-isophthalic acid diethyl ester: synthesis and investigation of antiarrhythmic properties. 92. Studies of pyran derivatives].