Drug Research 

About: Drug Research is an academic journal. The journal publishes majorly in the area(s): Pharmacokinetics & Cmax. It has an ISSN identifier of 0004-4172. Over the lifetime, 12628 publications have been published receiving 113901 citations.

The flavonoids. I

Abstract: Flavonoids are polyphenolic compounds that are ubiquitous in nature and are categorized, according to chemical structure, into flavonols, flavones, flavanones, isoflavones, catechins, anthocyanidins and chalcones. Over 4,000 flavonoids have been identified, many of which occur in fruits, vegetables and beverages (tea, coffee, beer, wine and fruit drinks). The flavonoids have aroused considerable interest recently because of their potential beneficial effects on human health­they have been reported to have antiviral, anti­allergic, antiplatelet, anti­inflammatory, antitumor and antioxidant activities.

Free radical scavenging activity of curcuminoids.

Abstract: Three natural curcuminoids (curcumin (CAS 458-37-7), demethoxycurcumin, bisdemethoxycurcumin) and acetylcurcumin were compared for their ability to scavenge superoxide radicals and to interact with 1,1-diphenyl-2-picryl-hydrazyl (DPPH) stable free radicals. The results showed that curcumin is the most potent scavenger of superoxide radicals followed by demethoxycurcumin and bisdemethoxycurcumin. Acetylcurcumin was inactive. Interaction with DPPH showed a similar activity profile. The study indicates that the phenolic group is essential for the free radical scavenging activity and presence of methoxy group further increases the activity.

Biochemistry and applications of aprotinin, the kallikrein inhibitor from bovine organs.

Abstract: The basic proteinase inhibitor from bovine organs, aprotinin (active ingredient of Trasylol) has been extensively studied with respect to its chemical, physical and biochemical properties and its inhibitory mechanism of action It is widely used as a valuable tool for studying protein/protein interactions and protein conformation at the molecular level There are numerous examples of the usefulness of aprotinin in biochemical and biomedical research It has also become a valuable drug for the treatment of various diseases like, eg hyperfibrinolytic hemorrhage and traumatic-hemorrhagic shock The purpose of this paper is threefold It summarizes our present knowledge of the subject in various disciplines; it provides the active scientist with basic data for his experimental work; and above all it points the way to future directions of aprotinin research