H
Haihua Gu
Researcher at Beth Israel Deaconess Medical Center
Publications - 29
Citations - 4662
Haihua Gu is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: GAB2 & Protein tyrosine phosphatase. The author has an hindex of 20, co-authored 23 publications receiving 4463 citations. Previous affiliations of Haihua Gu include Tufts University & Harvard University.
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The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
TL;DR: A small, highly conserved subfamily of protein-tyrosine phosphatases, members of which are present in both vertebrates and invertebrates, and the key targets of each Shp have remained elusive are identified.
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The ‘Gab’ in signal transduction
Haihua Gu,Benjamin G. Neel +1 more
TL;DR: The structure, mechanism of action and function of members of the Gab/Dos subfamily of scaffolding adaptor proteins play a crucial role in transmitting key signals that control cell growth, differentiation and function from multiple receptors are reviewed.
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Critical role for Gab2 in transformation by BCR/ABL
Martin Sattler,M. Golam Mohi,Yuri B. Pride,Laura R Quinnan,Nicole A Malouf,Klaus Podar,Franck Gesbert,Hiromi Iwasaki,Shaoguang Li,Richard A. Van Etten,Haihua Gu,James D. Griffin,Benjamin G. Neel +12 more
TL;DR: This work reports that Tyr177 recruits the scaffolding adaptor Gab2 via a Grb2/Gab2 complex and identifies Gab2 and its associated proteins as key determinants of the lineage and severity of BCR/ABL transformation.
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Divergent roles of SHP-2 in ERK activation by leptin receptors.
Christian Bjørbæk,Ryan M. Buchholz,Sarah M. Davis,Sarah H. Bates,Dominique D. Pierroz,Haihua Gu,Benjamin G. Neel,Martin G. Myers,Jeffrey S. Flier +8 more
TL;DR: It is shown that a catalytically inactive mutant of SHP-2 blocks leptin-stimulated ERK phosphorylation by the long leptin receptor, ObRb, and both the adaptor function and the phosphatase activity of SHp-2 are critical for this regulation.
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Essential role for Gab2 in the allergic response
Haihua Gu,Kan Saito,Lori D. Klaman,Junqing Shen,Tony Fleming,Yongping Wang,Joanne C. Pratt,Guosheng Lin,Bing Lim,Jean-Pierre Kinet,Benjamin G. Neel +10 more
TL;DR: Biochemical analyses reveal that signalling pathways dependent on PI(3)K, a critical component of FcεRI signalling, are defective in Gab2-/- mast cells, thereby providing genetic evidence that Dos/Gab family scaffolds regulate the PI( 3)K pathway in vivo.