H
Haim Tapiero
Researcher at Centre national de la recherche scientifique
Publications - 12
Citations - 117
Haim Tapiero is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Ornithine decarboxylase & Cytotoxicity. The author has an hindex of 7, co-authored 12 publications receiving 117 citations.
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Journal ArticleDOI
Effect of DNA-repair-enzyme modulators on cytotoxicity of L-phenylalanine mustard and cis-diamminedichloroplatinum (II) in mammary carcinoma cells resistant to alkylating drugs.
TL;DR: Results show that inhibition of DNA repair by HU+Ara-C or caffeine could be a target for modulation of bifunctional alkylating-drug resistance and that GSH depletion renders resistant cells more susceptible to the repair-enzyme modulators, suggesting that intracellular GSH may be involved in the regulation of some of these enzymes.
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Relationship between the intracellular level and growth inhibition of a new anthracycline 4′O-tetrahydropyranyl-adriamycin in friend leukemia cell variants
TL;DR: Studies comparing uptake and efflux of both drugs in ADM-resistant cells showed that THP-ADM extrusion correlate more to cytotoxicity than that of ADM.
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Apoptosis inhibition and ornithine decarboxylase superinduction as early epigenetic events in morphological transformation of Syrian hamster embryo cells exposed to 2-methoxyacetaldehyde, a metabolite of 2-methoxyethanol.
S. Dhalluin,Z. Elias,O. Poirot,Laurent Gate,Nicole Pages,Haim Tapiero,Paule Vasseur,G Nguyen-Ba +7 more
TL;DR: Such early cooperative events as apoptosis inhibition and ODC superinduction, followed by the increase of SHE-cell transformation frequency, are highly indicative of a carcinogenic potential for the metabolite, MALD.
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Dysregulation of ornithine decarboxylase activity, apoptosis and Bcl-2 oncoprotein in Syrian hamster embryo cells stage-exposed to di(2-ethylhexyl)phthalate and tetradecanoylphorbol acetate.
TL;DR: Both superinduction of ODC activity and inhibition of apoptosis via Bcl-2 upregulation, may cooperate during early stages of the carcinogenic process.
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Modulatory effect of dexamethasone on ornithine decarboxylase activity and gene expression: a possible post-transcriptional regulation by a neutral metalloprotease.
TL;DR: In turnover studies, DXME was found to increase the stability of ODC; the discrepancy between ODC activity and ODC mRNA levels could result from an inhibitory effect of the corticoid on proteolysis of O DC.