Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar,Mohali, Punjab-160 062, India, Institute of Biochemistry, Faculty of Medicine, Polytechnic University, Via Ranieri 67, IT-60100 Ancona, Italy,Green Biotechnology Research Group, The Special Division for Human Life Technology, National Institute of Advanced Industrial Science andTechnology, 1-8-31 Midorigaoka, Ikeda, Osaka-563-8577, Japan, and Department of Medicinal Chemistry & Natural Products,The Hebrew University of Jerusalem, School of Pharmacy-Faculty of Medicine, Jerusalem 91120, IsraelReceived March 2, 2004

Chitosan chemistry and pharmaceutical perspectives.

Chitosan—A versatile semi-synthetic polymer in biomedical applications

Nanoparticle-based targeted drug delivery

Implantable applications of chitin and chitosan

Polysaccharides-based nanoparticles as drug delivery systems

Synthesis and characterization of chitosan-poly(acrylic acid) nanoparticles.

Preparation, characterization, and drug release behaviors of drug nimodipine‐loaded poly(ε‐caprolactone)‐poly(ethylene oxide)‐poly(ε‐caprolactone) amphiphilic triblock copolymer micelles

Degradation behavior of poly(epsilon-caprolactone)-b-poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles in aqueous solution.

Copolymers of e-caprolactone and L-lactide (PCLLA) with different monomer ratio were synthesized by ring opening polymerization, and drug-loaded nanoparticles of poly-e-caprolactone (PCL), poly-L-lactide (PLLA), and their copolymers were prepared by precipitation method, respectively. The results of differential scanning calorimetry and X-ray diffraction indicated that the copolymerization of PCLLA decreased the crystallinity of the polymers, and the results of transmission electron micrograph and laser light scattering (LLS) revealed that the prepared nanoparticles had a spherical shape, and the size of PCLLA nanoparticles (∼ 85 nm) was smaller than that of the PCL and PLLA nanoparticles. The experiment of in vitro drug release showed that the drug release rate from PCLLA nanoparticles was slower than that from PCL and PLLA nanoparticles, and the release profile of PCL6/LA4 nanoparticles appeared to follow zero order kinetics. These results suggested that the polymer composition made a great influence on the nanoparticle size and drug release behavior. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 75: 874–882, 2000

Preparation, characterization, and drug release behaviors of drug‐loaded ε‐caprolactone/L‐lactide copolymer nanoparticles

To investigate the formation of positively charged nanoparticles (NP) stabilized with chitosan, positively charged poly(butyl cyanoacrylate) (PBCA) NP were prepared by emulsion polymerization in the presence of chitosan as a polymeric stabilizer at low pH. The effect of physicochemical factors such as the pH, the concentration and the volume of the chitosan solution, the chitosan molecular weight and the temperature on the mean particle size and the turbidity of PBCA-NP was investigated. Particle size was determined using a transmission electron microscope. The chemical interaction between chitosan and PBCA was identified by Fourier transform infrared (FT-IR) spectroscopy and the grafting percentage at various pH values was determined. The zeta potential of PBCA-NP coated with chitosan was determined from the electrophoretic mobility in 10 mM NaCl. The pH, the concentration and the volume of the chitosan solution and the molecular weight of chitosan were shown to be important factors in controlling the mean particle size of NP in the range 10–100 nm. FT-IR spectra indicated that chitosan was covalently linked to PBCA and the maximum grafting percentage reached about 120% w/w at pH 2.0. Nimodipine as a model drug was successfully incorporated into chitosan-stabilized PBCA-NP with a mean particle diameter of 31.6 nm. PBCA-NP coated with chitosan carried a positive charge. The results indicate that positively charged NP may be produced in the presence of cationic polysaccharide chitosan and might increase their potential use as a targeting drug delivery system.

Haixiong Ge

Papers

Synthesis and characterization of chitosan-poly(acrylic acid) nanoparticles.

Preparation, characterization, and drug release behaviors of drug nimodipine‐loaded poly(ε‐caprolactone)‐poly(ethylene oxide)‐poly(ε‐caprolactone) amphiphilic triblock copolymer micelles

Degradation behavior of poly(epsilon-caprolactone)-b-poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles in aqueous solution.

Preparation, characterization, and drug release behaviors of drug‐loaded ε‐caprolactone/L‐lactide copolymer nanoparticles

Formation of positively charged poly(butyl cyanoacrylate) nanoparticles stabilized with chitosan