H
Haiyan Wei
Researcher at Texas A&M University
Publications - 2
Citations - 183
Haiyan Wei is an academic researcher from Texas A&M University. The author has contributed to research in topics: Urea & Denaturation (biochemistry). The author has an hindex of 2, co-authored 2 publications receiving 171 citations.
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Effects of urea, tetramethyl urea, and trimethylamine N-oxide on aqueous solution structure and solvation of protein backbones: a molecular dynamics simulation study.
Haiyan Wei,Yubo Fan,Yi Qin Gao +2 more
TL;DR: Simulation results reveal the potential importance of the indirect effects of cosolvents in protein denaturation or structure protection, particularly through modifying of the water-amide interactions.
Journal ArticleDOI
Mutation of charged residues to neutral ones accelerates urea denaturation of HP-35.
TL;DR: The mechanism revealed here is consistent with the previous study on secondary structure of β-hairpin polypeptide, GB1, PEPTIDE 1, and TRPZIP4, suggesting that there is a general mechanism in the denaturation of protein backbone hydrogen bonds by urea.