H
Hajime Saito
Researcher at Akita University
Publications - 175
Citations - 2833
Hajime Saito is an academic researcher from Akita University. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 27, co-authored 160 publications receiving 2507 citations.
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Journal Article
Endothelial Myosin Light Chain Kinase Regulates Neutrophil Migration Across Human Umbilical Vein Endothelial Cell Monolayer
Hajime Saito,Yoshihiro Minamiya,Michihiko Kitamura,Satoshi Saito,Katsuhiko Enomoto,Kunihiko Terada,Jun-ichi Ogawa +6 more
TL;DR: Results indicate that a calcium/ calmodulin-dependent MLCK in endothelial cells regulates neutrophil transendothelial migration.
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Expression of histone deacetylase 1 correlates with a poor prognosis in patients with adenocarcinoma of the lung.
Yoshihiro Minamiya,Takashi Ono,Hajime Saito,Naoko Takahashi,Manabu Ito,Masafumi Mitsui,Satoru Motoyama,Jun-ichi Ogawa +7 more
TL;DR: Stronger HDAC1 expression by tumor cells is an independent predictor of a poor prognosis in patients with adenocarcinoma of the lung.
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Tumor-derived TGFβ-1 induces dendritic cell apoptosis in the sentinel lymph node
Manabu Ito,Yoshihiro Minamiya,Hideki Kawai,Satoshi Saito,Hajime Saito,Taku Nakagawa,Kazuhiro Imai,Makoto Hirokawa,Jun-ichi Ogawa +8 more
TL;DR: In this paper, the authors investigated the mechanism by which dendritic cell numbers were reduced within SLNs from patients with non-small cell lung cancer, and found that the incidence of apoptosis among DCs was higher in SLNs than in non-SLNs, as were levels of TGFβ-1.
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Endothelial Rho and Rho kinase regulate neutrophil migration via endothelial myosin light chain phosphorylation.
TL;DR: The results suggest that endothelial Rho and Rho kinase regulate transendothelial neutrophil migration by modulating the cytoskeletal events that mediate such migration.
Tumor-Derived TGFβ-1 Induces Dendritic Cell Apoptosis in the Sentinel Lymph Node
Manabu Ito,Yoshihiro Minamiya,Hideki Kawai,Satoshi Saito,Hajime Saito,Taku Nakagawa,Kazuhiro Imai,Makoto Hirokawa,Ogawa Jun-ichi +8 more
TL;DR: Results suggest that tumor-derived TGFβ-1 induces immunosuppression within SLNs before the movement of tumor cells into the SLNs, thereby facilitating metastasis within those nodes.