抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Internet of Things (IoT) is an emerging domain that promises ubiquitous connection to the Internet, turning common objects into connected devices. The IoT paradigm is changing the way people interact with things around them. It paves the way for creating pervasively connected infrastructures to support innovative services and promises better flexibility and efficiency. Such advantages are attractive not only for consumer applications, but also for the industrial domain. Over the last few years, we have been witnessing the IoT paradigm making its way into the industry marketplace with purposely designed solutions. In this paper, we clarify the concepts of IoT, Industrial IoT, and Industry 4.0. We highlight the opportunities brought in by this paradigm shift as well as the challenges for its realization. In particular, we focus on the challenges associated with the need of energy efficiency, real-time performance, coexistence, interoperability, and security and privacy. We also provide a systematic overview of the state-of-the-art research efforts and potential research directions to solve Industrial IoT challenges.

Industrial Internet of Things: Challenges, Opportunities, and Directions

Analysis of interactions among the barriers of reverse logistics

This guideline is based on a comprehensive review of the literature on pulmonary nodules and expert opinion. Although the management pathway for the majority of nodules detected is straightforward it is sometimes more complex and this is helped by the inclusion of detailed and specific recommendations and the 4 management algorithms below. The Guideline Development Group (GDG) wanted to highlight the new research evidence which has led to significant changes in management recommendations from previously published guidelines. These include the use of two malignancy prediction calculators (section ‘Initial assessment of the probability of malignancy in pulmonary nodules’, algorithm 1) to better characterise risk of malignancy. There are recommendations for a higher nodule size threshold for follow-up (≥5 mm or ≥80 mm3) and a reduction of the follow-up period to 1 year for solid pulmonary nodules; both of these will reduce the number of follow-up CT scans (sections ‘Initial assessment of the probability of malignancy in pulmonary nodules’ and ‘Imaging follow-up’, algorithms 1 and 2). Volumetry is recommended as the preferred measurement method and there are recommendations for the management of nodules with extended volume doubling times (section ‘Imaging follow-up’, algorithm 2). Acknowledging the good prognosis of sub-solid nodules (SSNs), there are recommendations for less aggressive options for their management (section ‘Management of SSNs’, algorithm 3).

The guidelines provide more clarity in the use of further imaging, with ordinal scale reporting for PET-CT recommended to facilitate incorporation into risk models (section ‘Further imaging in management of pulmonary nodules’) and more clarity about the place of biopsy (section ‘Non-imaging tests and non-surgical biopsy’, algorithm 4). There are recommendations for the threshold for treatment without histological confirmation (sections ‘Surgical excision biopsy’ and ‘Non-surgical treatment without pathological confirmation of malignancy’, algorithm 4).

Finally, and possibly most importantly, there are evidence-based recommendations about the information that people …

https://thorax.bmj.com/content/thoraxjnl/70/Suppl_2/ii1.full.pdf

British Thoracic Society guidelines for the investigation and management of pulmonary nodules: accredited by NICE

This review addresses the applicability of visible (Vis), near-infrared (NIR), and mid-infrared (MIR) reflectance spectroscopy for the prediction of soil properties. We address (1) the properties that can be predicted and the accuracy of the predictions, (2) the most suitable spectral regions for specific soil properties, (3) the number of predictions reported for each property, and (4) in-field versus laboratory spectral techniques.We found the following properties to be successfully predicted: soil water content, texture, soil carbon (C), cation exchange capacity, calcium and magnesium (exchangeable), total nitrogen (N), pH, concentration of metals/metalloids, microbial size, and activity. Generally, MIR produced better predictions than Vis-NIR, but Vis-NIR outperformed MIR for a number of properties (e.g., biological). An advantage of Vis-NIR is instrument portability although a new range of MIR portable devices is becoming available. In-field predictions for clay, water, total organic C, extra...

The Performance of Visible, Near-, and Mid-Infrared Reflectance Spectroscopy for Prediction of Soil Physical, Chemical, and Biological Properties

Accurate measurements of soil macronutrients (i.e., nitrogen, phosphorus, and potassium) are needed for efficient agricultural production, including site-specific crop management (SSCM), where fertilizer nutrient application rates are adjusted spatially based on local requirements. Rapid, non-destructive quantification of soil properties, including nutrient levels, has been possible with optical diffuse reflectance sensing. Another approach, electrochemical sensing based on ion-selective electrodes or ion-selective field effect transistors, has been recognized as useful in real-time analysis because of its simplicity, portability, rapid response, and ability to directly measure the analyte with a wide range of sensitivity. Current sensor developments and related technologies that are applicable to the measurement of soil macronutrients for SSCM are comprehensively reviewed. Examples of optical and electrochemical sensors applied in soil analyses are given, while advantages and obstacles to their adoption are discussed. It is proposed that on-the-go vehicle-based sensing systems have potential for efficiently and rapidly characterizing variability of soil macronutrients within a field.

Soil macronutrient sensing for precision agriculture

Purpose. To evaluate the prognostic value of the metabolic tumor volume measured on 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging and other clinical factors in patients treated for locally advanced head-and-neck cancer (HNC) at a single institution. Materials and methods. Between June 2005 and August 2008, 59 patients with HNC that underwent pretreatment FDG-PET studies received neoadjuvant chemotherapy and radiation therapy. Metabolically active tumor regions were delineated on the pretreatment PET scans by a fixed SUV of 2.5. We evaluated the relationship of the 18F-fluorodeoxyglucose-PET maximum standardized uptake value (SUV) and the metabolic tumor volume (MTV) with the progression-free survival (PFS) and overall survival (OS). Results. The MTV and lymph node metastasis were predictive of the PFS and OS. The lymph node status did not correlate with the MTV. A higher MTV of 9.3 cm3 was significantly associated with an increased risk of recurrence (2.19-fold, p = 0.006) ...

https://www.tandfonline.com/doi/pdf/10.3109/02841860903440270

Measurement of tumor volume by PET to evaluate prognosis in patients with head and neck cancer treated by chemo-radiation therapy

Rationale: Existing literature is inconclusive regarding how the nodular bronchiectatic form of Mycobacterium avium complex (MAC) disease will progress without treatment and when treatment initiation should be considered.Objectives: To assess the natural course of MAC pulmonary disease by serial thin-section computed tomography (CT).Methods: Of 339 patients with nodular bronchiectatic form of MAC disease, we selected 265 untreated patients who had serial CTs (mean observation period, 32 ± 21 mo). Two independent chest radiologists reviewed retrospectively all CT scans for the presence and extent of lung abnormalities (maximal total score, 30).Measurements and Main Results: Of 265 patients, 126 patients (48%) had disease that had progressed and that needed treatment owing to radiologic deterioration or worsening symptoms, and the remaining 139 patients (52%) did not. On multivariate analysis, the presence of cavity (adjusted hazard ratio, 2.06; P = 0.004) and consolidation (adjusted hazard ratio, 1.55; P =...

Nodular bronchiectatic Mycobacterium avium complex pulmonary disease. Natural course on serial computed tomographic scans.

Time-serial analysis of deep neural network models for prediction of climatic conditions inside a greenhouse

We report a case of cerebral phaeohyphomycosis due to Wangiella dermaitidis in an immunocompetent adult man. His cerebrospinal fluid (CSF) showed pleocytosis with a high eosinophil count but without peripheral blood eosinophilia. The present case suggested that this black yeast-like fungus should be included when the causes of CSF eosinophilia are considered, even though it is an extremely rare pathogen.

Hak-Jin Kim

Papers

Soil macronutrient sensing for precision agriculture

Measurement of tumor volume by PET to evaluate prognosis in patients with head and neck cancer treated by chemo-radiation therapy

Nodular bronchiectatic Mycobacterium avium complex pulmonary disease. Natural course on serial computed tomographic scans.

Time-serial analysis of deep neural network models for prediction of climatic conditions inside a greenhouse

Acute Cerebral Phaeohyphomycosis due to Wangiella dermatitidis Accompanied by Cerebrospinal Fluid Eosinophilia