H
Halina Offner
Researcher at Oregon Health & Science University
Publications - 315
Citations - 15366
Halina Offner is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & T cell. The author has an hindex of 61, co-authored 311 publications receiving 14301 citations. Previous affiliations of Halina Offner include Veterans Health Administration & United States Department of Veterans Affairs.
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Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis.
TL;DR: This is the first report demonstrating the use of a synthetic T CR V-region peptide to induce specific regulatory immunity and has important implications for the regulation of human disease characterized by common TCR V-gene usage.
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Experimental Stroke Induces Massive, Rapid Activation of the Peripheral Immune System:
Halina Offner,Sandhya Subramanian,Susan M. Parker,Michael Afentoulis,Arthur A. Vandenbark,Arthur A. Vandenbark,Patricia D. Hurn +6 more
TL;DR: Data show for the first time that focal cerebral ischemia results in dynamic and widespread activation of inflammatory cytokines, chemokines, and CCR in the peripheral immune system.
Journal ArticleDOI
Splenic Atrophy in Experimental Stroke Is Accompanied by Increased Regulatory T Cells and Circulating Macrophages
Halina Offner,Halina Offner,Sandhya Subramanian,Susan M. Parker,Chunhe Wang,Chunhe Wang,Michael Afentoulis,Anne D. Lewis,Arthur A. Vandenbark,Arthur A. Vandenbark,Patricia D. Hurn +10 more
TL;DR: New evidence is provided to support the contention that damage to the brain caused by cerebral ischemia provides a powerful negative signal to the peripheral immune system that ultimately induces a drastic state of immunosuppression caused by cell death as well as an increased presence of CD4+FoxP3+ regulatory T cells.
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Decreased FOXP3 levels in multiple sclerosis patients.
Jianya Huan,Nicole Culbertson,Nicole Culbertson,Leslie Spencer,Leslie Spencer,Richard M. Bartholomew,Gregory G. Burrows,Yuan K. Chou,Yuan K. Chou,Dennis Bourdette,Steven F. Ziegler,Halina Offner,Halina Offner,Arthur A. Vandenbark,Arthur A. Vandenbark +14 more
TL;DR: This study is the first to establish that MS patients have abnormalities in FOXP3 message and protein expression levels in peripheral CD4+CD25+ T cells (Tregs) that are quantitatively related to a reduction in functional suppression induced during suboptimal T‐cell receptor (TCR) ligation.
Journal ArticleDOI
T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation.
Patricia D. Hurn,Sandhya Subramanian,Susan M. Parker,Michael Afentoulis,Laurie J. Kaler,Arthur A. Vandenbark,Arthur A. Vandenbark,Halina Offner,Halina Offner,Halina Offner +9 more
TL;DR: The data quantify the damaging effect of T and B lymphocytes on early, evolving ischemic brain injury, and further implicate interleukin-1β in brain and interferon-γ and MIP-2 in spleen as inflammatory factors produced by cells other than T andB cells.