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Patricia D. Hurn
Researcher at University of Texas System
Publications - 118
Citations - 10368
Patricia D. Hurn is an academic researcher from University of Texas System. The author has contributed to research in topics: Stroke & Estrogen. The author has an hindex of 54, co-authored 117 publications receiving 9637 citations. Previous affiliations of Patricia D. Hurn include University of Texas at Austin & Johns Hopkins University.
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Journal ArticleDOI
Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations
Marc Fisher,Marc Fisher,Giora Z. Feuerstein,David W. Howells,Patricia D. Hurn,Thomas A. Kent,Sean I Savitz,Eng H. Lo +7 more
TL;DR: The updated STAIR preclinical recommendations reinforce the previous suggestions that reproducibly defining dose response and time windows with both histological and functional outcomes in multiple animal species with appropriate physiological monitoring is appropriate.
Journal ArticleDOI
Experimental Stroke Induces Massive, Rapid Activation of the Peripheral Immune System:
Halina Offner,Sandhya Subramanian,Susan M. Parker,Michael Afentoulis,Arthur A. Vandenbark,Arthur A. Vandenbark,Patricia D. Hurn +6 more
TL;DR: Data show for the first time that focal cerebral ischemia results in dynamic and widespread activation of inflammatory cytokines, chemokines, and CCR in the peripheral immune system.
Journal ArticleDOI
Estrogen as a neuroprotectant in stroke.
TL;DR: Gender-specific aspects of clinical and experimental stroke and results of estrogen treatment on outcome in animal models of cerebral ischemia are summarized, and potential vascular and parenchymal mechanisms by which estrogen salvages brain are discussed.
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Splenic Atrophy in Experimental Stroke Is Accompanied by Increased Regulatory T Cells and Circulating Macrophages
Halina Offner,Halina Offner,Sandhya Subramanian,Susan M. Parker,Chunhe Wang,Chunhe Wang,Michael Afentoulis,Anne D. Lewis,Arthur A. Vandenbark,Arthur A. Vandenbark,Patricia D. Hurn +10 more
TL;DR: New evidence is provided to support the contention that damage to the brain caused by cerebral ischemia provides a powerful negative signal to the peripheral immune system that ultimately induces a drastic state of immunosuppression caused by cell death as well as an increased presence of CD4+FoxP3+ regulatory T cells.
Journal ArticleDOI
T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation.
Patricia D. Hurn,Sandhya Subramanian,Susan M. Parker,Michael Afentoulis,Laurie J. Kaler,Arthur A. Vandenbark,Arthur A. Vandenbark,Halina Offner,Halina Offner,Halina Offner +9 more
TL;DR: The data quantify the damaging effect of T and B lymphocytes on early, evolving ischemic brain injury, and further implicate interleukin-1β in brain and interferon-γ and MIP-2 in spleen as inflammatory factors produced by cells other than T andB cells.