H
Hamida Saba
Researcher at University of Arkansas for Medical Sciences
Publications - 14
Citations - 514
Hamida Saba is an academic researcher from University of Arkansas for Medical Sciences. The author has contributed to research in topics: Kidney & Superoxide dismutase. The author has an hindex of 11, co-authored 14 publications receiving 474 citations.
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Journal ArticleDOI
Acetaminophen-Induced Hepatotoxicity in Mice Occurs with Inhibition of Activity and Nitration of Mitochondrial Manganese Superoxide Dismutase
Rakhee Agarwal,Lee Ann MacMillan-Crow,Tonya M. Rafferty,Hamida Saba,Dean W. Roberts,E. Kim Fifer,Laura P. James,Jack A. Hinson +7 more
TL;DR: The data indicate that Manganese superoxide dismutase inactivation by nitration is an early event in APAP-induced hepatic toxicity.
Journal ArticleDOI
Manganese Porphyrin Reduces Renal Injury and Mitochondrial Damage during Ischemia/Reperfusion
Hamida Saba,Ines Batinic-Haberle,Shankar Munusamy,Tanecia Mitchell,Cheryl F. Lichti,Judit Megyesi,Lee Ann MacMillan-Crow +6 more
TL;DR: This was the first study to examine the effects of MnTnHex-2-PyP(5+) in an animal model of oxidative stress injury and showed that porphyrin pretreatment of rats for 24 h protected against ATP depletion, MnSOD inactivation, nitrotyrosine formation, and renal dysfunction.
Journal ArticleDOI
The mitochondria-targeted antioxidant Mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys
Tanecia Mitchell,Dumitru Rotaru,Hamida Saba,Robin A.J. Smith,Michael P. Murphy,Lee Ann MacMillan-Crow +5 more
TL;DR: It is implicate that MitoQ could potentially be of therapeutic use for reducing organ preservation damage and kidney discardment and/or possibly improving renal function after transplantation.
Journal ArticleDOI
Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury.
TL;DR: Findings implicate mitochondrial superoxide, nitric oxide, and their reaction product, peroxynitrite, as key signaling molecules involved in CS.RW injury of renal tubular cells and suggest that therapeutic inhibition of these pathways may protect the donor kidney.
Journal ArticleDOI
Alteration of renal respiratory Complex-III during experimental type-1 diabetes
Shankar Munusamy,Hamida Saba,Tanecia Mitchell,Judit Megyesi,Robert W. Brock,Lee Ann MacMillan-Crow +5 more
TL;DR: Findings show for the first time that early (and selective) inactivation of Complex-III may contribute to the mitochondrial oxidant production which occurs in the early stages of diabetes.