Showing papers by "Hamish N. Munro published in 1971"
TL;DR: One hour after administration of L-dopa, there is a marked disaggregation of brain polysomes in immature rats, but adult animals show a similar response, but require larger doses of the amino acid.
Abstract: One hour after administration of L-dopa (50 to 300 milligrams per kilogram), there is a marked disaggregation of brain polysomes in immature rats. Adult animals show a similar response, but require larger doses of the amino acid (500 milligrams per kilogram). Single doses of L-dopa significantly elevate amounts of tryptophan in the brain; hence their effect on polysomes does not result from the unavailability of this amino acid.
60 citations
TL;DR: Transferase II from rat liver binds specifically at the ribosome receptor site, where Sulphydryl groups on both ribosomes and enzyme must be in the reduced state before binding is feasible.
Abstract: Transferase II from rat liver binds specifically at the ribosome receptor site. Sulphydryl groups on both ribosome and enzyme must be in the reduced state before binding is feasible.
25 citations
TL;DR: It has been concluded that corticosteroid hormones can cause aggregation of liver ribosomes through mechanisms not requiring synthesis of additional RNA.
15 citations
TL;DR: The experiments suggest that amanitin inhibits ribosomal RNA synthesis in vivo through some extranucleolar mechanism.
14 citations