Hannah S. Seidel

TL;DR: The data suggest that long-term maintenance of a balanced polymorphism has permitted the incompatibility in Caenorhabditis elegans to persist despite gene flow across the rest of the genome.

TL;DR: A method to infer the evolutionary history of a species from genome sequences of multiple individuals was developed and applied to whole-genome sequence data from three strains of Saccharomyces cerevisiae and the sister species SacCharomyces paradoxus and provides the initial foundation for population studies of association between genotype and phenotype in S. cerevisia.

TL;DR: A sperm-delivered toxin and an embryo-expressed antidote form a co-adapted gene complex in C. elegans that promotes its own transmission to the detriment of organisms carrying it.

TL;DR: In this paper, a sperm-delivered toxin, peel-1, and an embryo-expressed antidote, zeel-1 are shown to gain a transmission advantage through a combination of paternal-effect killing and zygotic self-rescue.

TL;DR: This new strain collection removes variation in the neuropeptide receptor gene npr-1, known to have large physiological and behavioral effects on C. elegans, and mitigates the hybrid strain incompatibility caused by zeel-1 and peel- 1, allowing for identification of quantitative trait loci that otherwise would have been masked by those effects.