The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors. While the organization of the book is similar to previous editions, major emphasis has been placed on disorders that affect multiple organ systems. Important advances in genetics, immunology, and oncology are emphasized. Many chapters of the book have been rewritten and describe major advances in internal medicine. Subjects that received only a paragraph or two of attention in previous editions are now covered in entire chapters. Among the chapters that have been extensively revised are the chapters on infections in the compromised host, on skin rashes in infections, on many of the viral infections, including cytomegalovirus and Epstein-Barr virus, on sexually transmitted diseases, on diabetes mellitus, on disorders of bone and mineral metabolism, and on lymphadenopathy and splenomegaly. The major revisions in these chapters and many

Harrison's Principles of Internal Medicine

[서평]「The Unified Modeling Language User Guide」

The Semantic Conception of Truth and the Foundations of Semantics

The current chapter presents an overview about the current stage of the foundational ontology GFO. GFO (General Formal Ontology). GFO is a foundational ontology integrating objects and processes. It is being developed by the research group Onto-Med (Ontologies in Medicine) at the University of Leipzig. Unique selling properties of GFO are the following: it includes categories of objects (3D objects) as well as of processes (4D entities) and both are integrated into one coherent framework. GFO presents a multi-categorial approach by admitting universals, concepts, and symbol structures and their interrelations. GFO adopts categories pertaining to levels of reality, and it is designed to support interoperability by principles of ontological mapping and reduction. GFO contains several novel ontological modules, in particular, a module for functions and a module for roles. GFO is designed for applications, firstly in medical, biological, and biomedical areas, but also in the fields of economics and sociology.

General Formal Ontology (GFO): A Foundational Ontology for Conceptual Modelling

Foundational Ontologies are theoretically well-founded domainindependent systems of categories that have been successfully used to improve the quality of conceptual modeling languages and models. In this paper, we present the latest developments in the UFO ontology. Moreover, we elaborate on the relevance of these foundational ontologies in the development of domain ontologies by showing a case study in the software process domain.

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Grounding Software Domain Ontologies in the Unified Foundational Ontology (UFO): The case of the ODE Software Process Ontology.

This report is a living document of the Research Group Ontologies in Medicine (Onto-Med) which represents work in progress towards a proposal for an integrated system of foundational ontologies. It will be applied to several fields of medicine, biomedicine, and biology, and a number of applications are carried out in collaboration with the Center for Clinical Trials at the University of Leipzig, with the MaxPlanck-Institute for Evolutionary Anthropology, and with the ICCAS at the University of Leipzig. The General Formal Ontology (GFO) is a component of the Integrated System of Foundational Ontologies (ISFO), and ISFO is a part of the Integrated Framework for the Development and Application of Ontologies (IFDAO). The predecessor of IFDAO was the GOL project which was launched in 1999 as a collaborative research effort of the Institute of Medical Informatics, Statistics and Epidemiology (IMISE) and the Institute of Informatics (IfI) at the University of Leipzig.

Hannes Michalek

Papers

General Formal Ontology (GFO) - A Foundational Ontology Integrating Objects and Processes [Version 1.0]